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GingisKHAN® (KGP)

GingisKHAN enzyme is a unique protease that digests human IgG1 between K223 and T224 producing a homogenous pool of Fab and Fc fragments. The enzyme requires only mild reduced condition for activity and the reaction is performed in the presence of 2 mM Cystein at neutral pH, leaving intact Fab and Fc fragments.

Key Characteristics

  • Specific - one precise cleavage site in upper hinge of human IgG1
  • Rapid – 60 minute protocol for complete digestion
  • Comes with ready to use reaction buffer additive for convenient and reliable performance

GingisKHAN® Digestion Site

Human IgG1 ..KSCDK/ THTCPPCP..

Visit Applications to view the IgG protease digestion chart

Product Formats

GingisKHAN® Enzyme

GingisKHAN enzyme supplied as lyophilized powder together with 5 vials of lyophilized GingisKHAN reducing agent for convenient and reliable performance. The enzyme is available in 2000 unit vial (1 unit digest 1 ug IgG).

GingisKHAN® Fab kit

GingisKHAN Fab kit is used for rapid and easy preparation and purification of of Fab fragments from human IgG1 antibodies. The kit consists of two parts; lyophilized GingisKHAN enzyme and affinity spin columns for purification of intact Fab fragments.

Documents and References

Enzyme Reference Tool

All published papers on how Genovis enzymes help simplify antibody analytics
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FAQ and Support

FAQ

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Patent and Disclaimer

GingisKHAN®

The trademark GingisKHAN is the property of Genovis AB.

For research use only. Not intended for any animal or human therapeutic diagnostic use.
©2016 Genovis AB.