NEW! We’re Launching ImpaRATOR™!
We are excited to launch ImpaRATOR, an O-glycan-dependent protease that digests proteins carrying mucin-type O-glycans, including sialylated species, N-terminally of glycosylated Ser and Thr residues!
The enzyme generates glycopeptides carrying O-glycans, which enables O-glycan profiling, site occupancy determination and O-glycopeptide mapping as well as middle-level approaches using LC-MS analysis.
Read more »
NEW! We’re Launching IgMBRAZOR™!
IgMBRAZOR is a unique IgM-specific protease that digests human IgM at one specific site below the CH2 domain in the heavy chain, generating homogeneous F(ab’)2 and Fc fragments. We’re excited to launch this unique tool today that enables middle-level analysis of the complex and high molecular weight human IgM!
IgMBRAZOR facilitates IgM characterization during, for example, the development of vaccines, therapeutics, and diagnostics. The digestion is complete within 30 minutes, and due to the specificity of the enzyme, there is no risk of overdigestion if the incubation time is prolonged.
Read more »
Collaboration Agreement
Genovis and ArcticZymes are excited to announce a collaboration to speed up penetration and growth in the Chinese market.
Read more »
IP Rights to Novel Enzymes for Applications within Genomics
Today, Genovis has acquired the patent rights to a unique DNA polymerase developed by researchers at Uppsala University. The enzyme has potential applications in research, diagnostics and forensics.
Read more »
Sign Up for our Next GenovisWebinar!
We are excited to announce the speaker and topic for our next GenovisWebinar!
Read more »
Mechanistic Insights to Drive Rational Design of Masked Antibodies using FabALACTICA®
Scientists at the University of Cambridge, Astra Zeneca and collaborators undertook mechanistic studies to investigate antibody masking and better understand the parameters involved and their relative impact. FabALACTICA proved to be a valuable tool in this study, allowing the authors to generate antibody subunits. Using the Fab region, as opposed to the full-length antibody, allowed for both higher resolution SEC-MALS experiments to be performed, and supported structural determination of the complexes.
Read more »
NEW! We’re Launching GlySERIAS Immobilized
GlySERIAS is a unique enzyme that digests flexible glycine-rich fusion protein linkers such as Gly4Ser and GlyxSery (GS), and polyglycine (G) linkers. Today, we’re happy and proud to be launching this unique SmartEnzyme in a new format – GlySERIAS Immobilized – for digestion of flexible linkers in easy-to-use spin columns!
The enzyme enables separation of the individual domains of multi-functional fusion proteins to facilitate characterization and increase the understanding of these molecules. Middle-level analysis of fusion proteins serves to both reduce the overall sample complexity and allow for domain-specific identification and monitoring of post-translational modifications.
For improved linker removal, we recommend GlySERIAS Immobilized.
For linker characterization, we recommend GlySERIAS Lyophilized.
Read more »
It’s Time for a Change!
As part of our overall strategy to become even more sustainable and caring for the environment, we are updating our product boxes (see below). When updating the boxes, we also want to make it easier for you to know what you get when you buy or search for a product from us. We are therefore creating a clearer structure regarding our product naming!
Read more »
FabULOUS™ in HIV Vaccine Research
The Fc N-glycosylation profile can be linked to non-neutralizing functions in a vaccine. In a recent study by Chen et al., FabULOUS digestion provided valuable insights in HIV vaccine research following N-glycosylation analysis of the Fc region in mouse antibodies.
Read more »
Welcome to Join Our First GenovisWebinar!
We are excited to announce our series of GenovisWebinars, and we are happy to invite you to the first webinar held on November 17th!
Each webinar will showcase inspirational SmartEnzymes user, and the topics discussed are influenced by how to improve analytical workflows. Please join us in sharing experiences!
Read more »