Simple and rapid workflow for native antigen release from Fc-affinity captured antibody complexes for downstream characterization and validation.
Applications
Explore how our solutions are used across a range of applications. From sample preparation to advanced analysis, you can find insights into how they support different workflows and help address common challenges.
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Single-resin affinity platform capturing all Immunoglobulin isotypes from serum, enabling high-resolution proteomic analysis of Ig and non-Ig fractions.
Broad immunoglobulin capture across multiple isotypes using Fab-targeted binding for simplified, immuno-profiling workflows.
Native antigen release from antibody-antigen complexes, enabling downstream functional, structural, and biological characterization of otherwise hidden targets.
Efficient IgG cleavage with a low immunogenicity risk enzyme, supporting clearance of neutralizing antibodies to improve gene therapy administration.
Inhibition by synthetic RNase inhibitor (SEQURNA) matches or surpasses recombinant inhibitors in Smart‑seq2 and Smart-seq3 library preparation, including RNase‑rich tissues.
Synthetic RNase inhibition maintains Smart‑seq2 cDNA yield and quality comparable to protein-based RRIs while decreasing primer‑dimer formation.
Simplified charge variant analysis by removing sialic acid-driven heterogeneity to reveal underlying protein profile.
Complete desialylation of complex glycoproteins to simplify glycan profiles and enable more confident protein characterization.
Efficient removal of core 1 O-glycans from complex glycoproteins to reduce heterogeneity and improve mass spectrometry characterization.
Preparation of pure, homogeneous mouse IgG Fab fragments with no residual enzyme by combining FabULOUS digestion and affinity purification.
Simple preparation of highly pure Fab fragments from IgG1 antibodies using FabALACTICA digestion combined with Fc affinity purification.
