Antibody DOL Determination
Service
Our DOL determination service utilizes high-resolution LC-MS to accurately characterize antibody conjugates.
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Fast DOL Determination of Conjugated Antibodies by LC-MS
Accurate determination of degree of labeling (DOL) is essential for understanding conjugation efficiency and ensuring consistent product quality. Our LC-MS-based service enables fast and reliable DOL analysis of conjugated antibodies, providing insights into both the average DOL and its distribution – key quality attributes for research reagents and therapeutics. With minimal sample preparation and high-resolution data, you can make confident decisions without delays
Why Antibody DOL Determination service from Genovis?
- High-resolution mass spectrometry for precise DOL determination
- Detailed reporting of average DOL and distribution
- Unique SmartEnzyme workflow performed by our expert MS team
About the Antibody DOL Determination Service
The DOL of a conjugated antibody is a key quality attribute that directly impacts the function of the conjugate. Reliable DOL analysis is therefore essential.
Our Antibody DOL Determination service includes LC-MS analysis of both the reference and conjugated antibody. Samples are deglycosylated using specific and efficient SmartEnzymes™ and analyzed at the intact level. Results are presented in an easy-to-interpret report.
How it Works
Contact us and share specifics about your antibody with our MS experts, then send your samples (>100µg), including both non-conjugated reference antibody and conjugated antibody.
We apply our unique SmartEnzymes sample preparation workflows and perform LC-MS analysis using high-quality instrumentation.
Within 5 working days, you receive a detailed, easy-to-interpret LC-MS report covering key antibody quality attributes: average DOL, DOL distribution (%), and mass confirmation.
Pricing
| Substrate | Product ID | Quantity | Results | Price |
|---|---|---|---|---|
| Human IgG | W0-SMA-005 | >100 ug each of reference and conjugated mAb | Within 5 working days | 1406 EUR 1682 USD |
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Do you have any questions, or would like to know more? Contact us!