IgMBRAZOR™ GTx Preclinical – Digestion of IgM
IgMBRAZOR is a unique IgM-specific protease that digests human IgM at one specific site below the CH2 domain in the heavy chain, generating homogeneous F(ab’)2 and Fc fragments.
SmartEnzymes™
IgMBRAZOR™ GTx Preclinical Grade is an IgM-specific protease with validated low endotoxin levels, developed for in vivo preclinical research into IgM-mediated disease and immunomodulation. It digests human IgM at a single site in the heavy chain, dismantling the pentameric structure that drives complement activation and avid antigen binding, for rapid reduction of pathogenic IgM in gene therapy, autoimmunity, and transplantation research models.
Why IgMBRAZOR™ GTx Preclinical?
- First-in-class – uniquely enables selective in vivo IgM reduction without disrupting IgG-mediated immunity
- Validated low endotoxin – controlled levels suitable for in vivo preclinical applications
- Broadly applicable – supports in vivo research in gene therapy, autoimmunity, and transplantation
Human IgM
30 min reaction
No need for reducing agents or co-factors
VPDQDT / AIRVFA (in the heavy chain)
Product Formats
About IgMBRAZOR™ GTx Preclinical
IgMBRAZOR GTx Preclinical Grade is a protease that digests human IgM at a single site in the heavy chain, generating a homogeneous pool of F(ab’)2 and Fc fragments that cannot reassemble into functional pentamers. IgM is the only known substrate, which makes IgMBRAZOR GTx suitable for use in complex samples and in vivo.
In vivo IgM cleavage addresses an immune arm that complements IgG-directed approaches. As a pentamer, IgM binds antigen avidly and activates complement potently; selective IgM reduction dismantles these functions without disrupting IgG-mediated protective immunity. Applications range from mitigating complement-driven vector injury in gene therapy to preclinical research in IgM-mediated autoimmunity and antibody-mediated rejection in transplantation.
IgMBRAZOR GTx Preclinical Grade is manufactured with validated and controlled low endotoxin levels, making it suitable for a wide range of in vivo preclinical studies. The enzyme is recombinantly expressed in E. coli. It carries a His-tag and has a molecular weight of 38 kDa.
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