AlligBAITOR™ – All Ig Capture and Antigen Release
AlligBAITOR is an immunoglobulin-binding protein that binds all human immunoglobulin isotypes and subclasses. Upon AlligBAITOR binding, any bound antigen is released from the immune complex.
SmartEnzymes™
AlligBAITOR is recombinantly produced to high purity and is suitable for a wide range of potential applications which will be facilitated by human immunoglobulin capture or native antigen release. AlligBAITOR is available in two formats: Lyophilized and Affinity Purification.
Why AlligBAITOR™?
- Efficient binding of all isotypes and subclasses of human immunoglobulins
- Native antigen release from immune complexes
- Effective immunoglobulin depletion of complex samples, such as human serum
All human immunoglobulin isotypes (IgG, IgM, IgA, IgD, IgE) and subclasses
30 min – 2 hr
No need for reducing agents or cofactors
Binds by encircling the immunoglobulin Fab domain
Product Formats
About AlligBAITOR™
AlligBAITOR is a recombinantly produced, pan-immunoglobulin binding protein that binds all human immunoglobulin isotypes and subclasses.
AlligBAITOR enables rapid and high-affinity capture of immunoglobulins and, upon binding, drives the release of bound antigens from immune complexes under native conditions. AlligBAITOR supports a wide range of potential applications requiring global immunoglobulin binding or native antigen release. For applications requiring native antigen release, we recommend AlligBAITOR Lyophilized, for applications involving global immunoglobulin binding or immunoglobulin depletion of complex samples, we recommend AlligBAITOR Affinity Purification. AlligBAITOR is active in a wide range of physiological relevant buffer conditions, including PBS and TBS, in a salt concentration up to 500 mM and in the pH range 5.5 – 8.5.
Applications
Native antigen release from antibody-antigen complexes, enabling downstream functional, structural, and biological characterization of otherwise hidden targets.
Broad immunoglobulin capture across multiple isotypes using Fab-targeted binding for simplified, immuno-profiling workflows.
Single-resin affinity platform capturing all Immunoglobulin isotypes from serum, enabling high-resolution proteomic analysis of Ig and non-Ig fractions.
Simple and rapid workflow for native antigen release from Fc-affinity captured antibody complexes for downstream characterization and validation.
FAQ and Support
Can you use the Affinity Purification format for antigen release?
For antigen release experiments, we recommend using AlligBAITOR Lyophilized. Immobilization of the AlligBAITOR can limit its ability to release antigens in a fully efficient manner.
Does AlligBAITOR bind only to human immunoglobulins?
No, we have also seen binding activity towards immunoglobulins of other species (goat, rabbit and mouse) using AlligBAITOR.
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