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Enzymes for Biopharmaceuticals
Genovis provides unique enzymes and technologies for analytical characterization and conjugation of biopharmaceuticals. The SmartEnzymes™ portfolio consists of FabRICATOR® (IdeS), FabRICATOR®Z (IdeZ), FabALACTICA® (IgdE), FabULOUS™ (SpeB), GingisKHAN® (KGP), GingisREX® (Rgp), IgGZERO® (EndoS), GlycINATOR® (EndoS2), OpeRATOR®, GlycOCATCH™, OglyZOR®, SialEXO® and the antibody conjugation technology GlyCLICK®.
News
2020-12-10: GlyCLICK ADC Products
Create a site-specific ADC with one of the new GlyCLICK ADC kits that arms any antibody with unique linker-payloads. Learn more and find the kit for your next ADC development!
2020-09-30: New SmartEnzyme - GalNAcEXO™
Adiós GalNAcs - remove core GalNAcs using GalNAcEXO™!
GalNAcEXO is an enzyme for the hydrolysis of GalNAc residues, known as Tn antigens, on O-glycosylated proteins. Hydrolyze Tn antigens to fully deglycosylate the protein and reveal other hidden critical quality attributes.
2020-09-23: New SmartEnzyme - Immobilized GalactEXO™
We are launching Immobilized GalactEXO™!
Immobilized GalactEXO consists of the powerful GalactEXO immobilized on agarose beads and formatted in an easy-to-use microspin column format. GalactEXO is a mix of β-galactosidases for efficient removal of galactose residues on N- and O-glycosylated proteins.
2020-07-08: New SmartEnzyme - GalactEXO™
Genovis presents GalactEXO - a new galactosidase for efficient hydrolysis of galactose. The new GalactEXO hydrolyzes β1-3 and β1-4 linked galactose from 2 mg glycoprotein in 2 h. The enzyme can be used for exoglycosidase sequencing and to generate antibodies with homogenous GOF glycoforms.
2020-06-04: FabRICATOR® MagIC!
We are launching a New SmartEnzyme, FabRICATOR® MagIC!
FabRICATOR® MagIC contains the IgG-specific FabRICATOR (IdeS) enzyme immobilized on magnetic beads for automated and parallel middle-level workflows for analysis of antibodies.
2020-05-28: Launch of New GlyCLICK® kits!
Our site-specific antibody conjugation technology, GlyCLICK, is now even more colorful. We’re now adding AlexaFluor® 555 and AlexaFluor® 647 to our portfolio!
Find all available formats in our Store or read about GlyCLICK on the product page.
Meet us at
- Festival of Biologics Series 2020 Nov 2-6, Virtual Conference
Latest References
- Generating Informative Sequence Tags from Antigen-Binding Regions of Heavily Glycosylated IgA1 Antibodies by Native Top-Down Electron Capture Dissociation
2021-02-11
Jean-Francois Greisch, Maurits A. den Boer, Frank Beurskens, Janine Schuurman, Sem Tamara, Albert Bondt, Albert J. R. Heck - Microdroplet Ultrafast Reactions Speed Antibody Characterization
2021-02-05
Pengyi Zhao, Harsha P. Gunawardena, Xiaoqin Zhong, Richard N. Zare and Hao Chen - C-terminal lysine clipping of IgG1: impact on binding to human FcγRIIIa and neonatal Fc receptors
2021-01-18
Valegh Faid, Yann Leblanc, Marie Berger, Alexander Seifert, Nicolas Bihoreau, Guillaume Chevreux