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Site-specific conjugation of native antibodies


Enzymes for O-glycans

Site-specific O-glycan analysis using the new OpeRATOR® protease



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IgG Glycosidases



Genovis provides unique enzymes and technologies for analytical characterization and conjugation of biopharmaceuticals. The SmartEnzymes™ portfolio consists of FabRICATOR® (IdeS), FabRICATOR®Z (IdeZ), FabALACTICA® (IgdE)FabULOUS® (SpeB), GingisKHAN® (KGP), GingisREX® (Rgp), IgGZERO® (EndoS)GlycINATOR® (EndoS2), OpeRATOR®, GlycOCATCH™OglyZOR®, SialEXO® and the antibody conjugation technology GlyCLICK®.


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2019-10-08: Genovis Launches GlyCLICK 2 mg

GlyCLICK is a site-specific conjugation technology for IgG using enzymatic remodeling of the Fc-glycans and click-chemistry. The GlyCLICK technology is available in a range of kit formats to facilitate tailored and site-specific labeling of antibodies. GlyCLICK for azide activation of 2 mg of antibody is available for purchasing today.

2018-04-26: Genovis Launches GlycOCATCH™

GlycOCATCH is an enrichment resin for affinity purification of O-glycosylated proteins and peptides. The resin is designed to bind proteins and peptides carrying O-glycans with high affinity, and it is provided in convenient spin columns to allow easy-to-use O-glycoprotein enrichment. The GlycOCATCH product is available for purchasing today.

Antibody Glycation Study using Intact LC-MS 

IgGZERO is starring a newly published study demonstrating the use of intact mass spectrometry to determine the level of glycation on therapeutic antibodies. To perform the assay, IgGZERO was used to rapidly remove the Fc-glycans.

A New Assay to Study Antibody Disulphide Bonds using FabRICATOR and FabALACTICA

In a recently published article, FabRICATOR was used to digest below the hinge and FabALACTICA above the hinge of human IgG1, generating three fragments; the hinge peptide, the Fab and the Fc/2 fragments. This setup enables analysis of both inter- and intrachain disulphide bonds, as well as other quality attributes.

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IgG Cleavage

IgG Proteases

Specific digestion of IgG with activity on human IgG1-4 as well as other species



Learn more about the applications of Genovis SmartEnzymes for mass-spectrometry analysis of antibodies, antibody oxidation assay and more.

Smart Enzyme Reference Tool

SmartEnzyme Reference Tool

Find the right reference for the antibody attribute you are studying

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