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Applications Enzymes for Biopharmaceuticals


Learn about the applications of Genovis Enzymes for Biopharmaceuticals.


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Genovis Continues Operation

Genovis continues operation and remain committed to serve our customers during the ongoing pandemic crisis. Read more here.

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IgG Glycosidases


SialEXO 23



Enzymes for Biopharmaceuticals

Genovis provides unique enzymes and technologies for analytical characterization and conjugation of biopharmaceuticals. The SmartEnzymes™ portfolio consists of FabRICATOR® (IdeS), FabRICATOR®Z (IdeZ), FabALACTICA® (IgdE)FabULOUS® (SpeB), GingisKHAN® (KGP), GingisREX® (Rgp), IgGZERO® (EndoS)GlycINATOR® (EndoS2), OpeRATOR®, GlycOCATCH™OglyZOR®, SialEXO® and the antibody conjugation technology GlyCLICK®.


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2020-07-08: GalactEXO

Genovis presents GalactEXO - a new galactosidase for efficient hydrolysis of galactose. The new GalactEXO hydrolyzes β1-3 and β1-4 linked galactose from 2 mg glycoprotein in 2 h. The enzyme can be used for exoglycosidase sequencing and to generate antibodies with homogenous GOF glycoforms.

2020-06-04: FabRICATOR® MagIC!

We are launching a New SmartEnzyme, FabRICATOR® MagIC!
FabRICATOR® MagIC contains the IgG-specific FabRICATOR (IdeS) enzyme immobilized on magnetic beads for automated and parallel middle-level workflows for analysis of antibodies.

2020-05-28: Launch of New GlyCLICK® kits!

Our site-specific antibody conjugation technology, GlyCLICK, is now even more colorful. We’re now adding AlexaFluor® 555 and AlexaFluor® 647 to our portfolio!
Find all available formats in our Store or read about GlyCLICK on the product page.

2020-04-24: SmartStories - Share your experience, be a Smartscientist

At Genovis, we firmly believe that sharing scientific achievements and experiences will lead to new ideas and insights that will contribute to better biologics for patients. Take the opportunity to share your work on Genovis SmartStories and inspire others to follow your lead.

2020-04-03: Digested News Live - YouTube Webinar

We hosted Digested News LIVE on April 3rd and the webinar is freely available on the Genovis YouTube channel.

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IgG Cleavage

IgG Proteases

Specific digestion of IgG with activity on human IgG1-4 as well as other species


Site-specific conjugation of native antibodies

Smart Enzyme Reference Tool

SmartEnzyme Reference Tool

Find the right reference for the antibody attribute you are studying

Latest References

  • Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry
    Kristina Srzentic, Luca Fornelli, Yury O. Tsybin, Joseph A. Loo, Henrique Seckler, Jeffrey N. Agar, Lissa C. Anderson, Dina L. Bai, Alain Beck, Jennifer S. Brodbelt, Yuri E.M. van der Burgt, Julia Chamot-Rooke, Sneha Chatterjee, Yunqiu Chen, David James Clarke, Paul O. Danis, Jolene K. Diedrich, Robert Anthony D'Ippolito, Mathieu Dupré, Natalia Gasilova, Ying Ge, Young Ah Goo, David R. Goodlett, Sylvester M. Greer, Kim F. Haselmann, Lidong He, Christopher L. Hendrickson, Joshua D. Hinkle, Matthew Holt, Sam Hughes, Donald F. Hunt, Neil L Kelleher, Anton N. Kozhinov, Ziqing Lin, Christian Malosse, Alan G. Marshall, Laure Menin, Robert J. Millikin, Konstantin O. Nagornov, Simone Nicolardi, Ljiljana Paša-Tolić, Stuart Pengelley, Neil R. Quebbemann, Anja Resemann, Wendy Sandoval, Richa Sarin, Nicholas Daniel Schmitt, Jeffrey Shabanowitz, Jared B. Shaw, Michael R. Shortreed, Lloyd M. Smith, Frank Sobott, Detlev Suckau, Timothy Toby, Chad R. Weisbrod, Norelle C. Wildburger, John R. Yates, Sung Hwan Yoon, Nicolas L. Young, and Mowei Zhou
  • Large-scale site-specific mapping of the O-GalNAc glycoproteome
    Weiming Yang, Angellina Song, Minghui Ao, Yuanwei Xu & Hui Zhang
  • High microbiota reactivity of adult human intestinal IgA requires somatic mutations
    Johanna Kabbert, Julia Benckert, Tim Rollenske, Thomas C.A. Hitch, Thomas Clavel, Vuk Cerovic, Hedda Wardemann, Oliver Pabst