From the Blog |
Genovis provides unique enzymes and technologies for analytical characterization and conjugation of biopharmaceuticals. The SmartEnzymes™ portfolio consists of FabRICATOR® (IdeS), FabRICATOR®Z (IdeZ), FabALACTICA™ (IgdE), FabULOUS® (SpeB), GingisKHAN® (KGP), GingisREX™ (Rgp), IgGZERO® (EndoS), GlycINATOR® (EndoS2), OpeRATOR™, GlycOCATCH™, OglyZOR™, SialEXO™ and the antibody conjugation technology GlyCLICK™.
News
2018-04-26: Genovis Launches GlycOCATCH™
GlycOCATCH is an enrichment resin for affinity purification of O-glycosylated proteins and peptides. The resin is designed to bind proteins and peptides carrying O-glycans with high affinity, and it is provided in convenient spin columns to allow easy-to-use O-glycoprotein enrichment. The GlycOCATCH product is available for purchasing today.
Antibody Glycation Study using Intact LC-MS
IgGZERO is starring a newly published study demonstrating the use of intact mass spectrometry to determine the level of glycation on therapeutic antibodies. To perform the assay, IgGZERO was used to rapidly remove the Fc-glycans.
A New Assay to Study Antibody Disulphide Bonds using FabRICATOR and FabALACTICA
In a recently published article, FabRICATOR was used to digest below the hinge and FabALACTICA above the hinge of human IgG1, generating three fragments; the hinge peptide, the Fab and the Fc/2 fragments. This setup enables analysis of both inter- and intrachain disulphide bonds, as well as other quality attributes.
Meet us at
- American Society for Mass Spectrometry ASMS
Jun 2-6, 2019
Atlanta, USA
Brochures and Posters
Download Genovis brochures and posters with the latest details on the SmartEnzymes
Applications
Learn more about the applications of Genovis SmartEnzymes for mass-spectrometry analysis of antibodies, antibody oxidation assay and more.
Latest References
- Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry
2018-12-20
Yuri E.M. van der Burgt, David P. A. Kilgour, Yury O. Tsybin, Kristina Srzentic,́ Luca Fornelli, Alain Beck, Manfred Wuhrer, and Simone Nicolardi - A generic workflow for the characterization of therapeutic monoclonal antibodies—application to daratumumab
2018-12-19
Bastiaan L. Duivelshof & Szabolcs Fekete & Davy Guillarme & Valentina D’Atri - Orthogonal Middle-up Approaches for Characterization of the Glycan Heterogeneity of Etanercept by Hydrophilic Interaction Chromatography Coupled to High-Resolution Mass Spectrometry
2018-12-04
Valentina D’Atri, Lucie Novaḱova, Szabolcs Fekete, Dwight Stoll, Matthew Lauber, Alain Beck, and Davy Guillarme