SEQURNA® – Securing RNA for Sequencing

SEQURNA Thermostable RNase Inhibitor is a fully synthetic and heat-tolerant inhibitor that protects RNA integrity.

Genomics

SEQURNA is active across a wide temperature range, provides sustainability through ambient storage and shipping, minimizes batch effects, and avoids activity loss from freeze-thaw cycles and long incubation times. This makes it ideal for applications such as single-cell and in situ RNA sequencing, where preserving high-quality RNA is essential.

By preserving RNA during crucial steps like cell lysis, RNA storage, and reverse transcription, SEQURNA ensures that sensitive samples remain intact, which is critical in workflows that require precise RNA quantification and sequencing, such as single-cell RNA-sequencing and spatial transcriptomics. SEQURNA Thermostable RNase Inhibitor enhances reproducibility and data accuracy, streamlines experimental workflows, and expands the potential for developing novel protocols that include temperature variations.

Why SEQURNA®?

  • Thermostable – active across a wide temperature range, ensuring reliable RNA protection in heat-based workflows, simplifying logistics and enabling flexible protocol development
  • Synthetic – reduces batch variability for consistent results, with no risk of introducing cell-based contaminants from production
  • Versatile – preserves RNA integrity across various workflows, including single-cell and in situsequencing
  • Sustainable – energy-efficient synthesis and storage, with ambient shipping and room temperature stability – no dry ice shipments!

  • Target

    Inhibition of RNase

  • Box

    No need for reducing agents such as DTT

  • Info

    Synthetic, thermostable RNase inhibitor

  • Temperature

    Stored at room temperature (15-30°C)

Product Formats

About SEQURNA®

SEQURNA Thermostable RNase Inhibitor consists of a proprietary mix of synthetic molecules that protects RNA by interfering with the active site of RNases. It is the ideal choice in library preparation for single-cell RNA sequencing, in situ RNA sequencing, multiomics applications, or other methods that rely on consistent RNase inhibition.

The SEQURNA RNase Inhibitor is thermostable, enduring 55°C for 24 hours or 70°C for 2 hours, and can tolerate even harsher experimental conditions, such as 95°C for shorter periods. This ensures robust RNA protection throughout and after heat cycles, outperforming commonly used protein-based recombinant RNase inhibitors. The stability of the inhibitor enables the development of new workflows and enhances RNA integrity over longer experimental timelines, as well as during sample handling and storage.

SEQURNA Thermostable RNase Inhibitor tolerates freeze/thaw cycles and vigorous vortexing, requires no DTT, and remains active across a broad pH range of 4.0-10.0.

Applications

Citations

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FAQ and Support

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