Join Us for Our Next GenovisWebinar – Solve Analytical Challenges with SmartEnzymes™!
We are happy to welcome Angela Capolupo from Merck Serono to talk about how implementing Genovis SmartEnzymes in their workflows has allowed her and her team to resolve complex analytical and structural problems!
FabALACTICA® is an enzyme that digests human IgG1 at a specific site above the hinge, generating intact and homogeneous Fab and Fc fragments for middle-level characterization of antibody components. GlySERIAS™ is a unique enzyme for digestion of flexible glycine-rich fusion protein linkers. Using these two enzymes in combination, Angela and her team solved a challenging puzzle and unravelled the intricate structure of an unknown molecule step-by-step.
Register for the webinar now and learn more!
Title:“How to Solve an Enigma using Orthogonal Enzymatic Approaches for Biopharmaceutical Characterization”
Date: September 26th, 2024
Time: 4 pm CET / 10 am EST
REGISTER HERE!
Key Learning Objectives
- The importance of sample preparation and advantages of middle-level analysis
- Use of SmartEnzymes for the characterization of biopharmaceuticals
- Combining orthogonal enzymatic approaches to facilitate deeper understanding of proteins by focusing on individual domains
Who Should Attend?
- Scientists involved in the MS characterization of biopharmaceuticals
- Scientists working in Quality Control (QC) labs
- Scientists performing middle-level analysis of mAbs
- Contract Research Organizations (CROs)
- Contract Manufacturing Organizations (CMOs)
- Academic scientists working with protein characterization by MS
About FabALACTICA®
FabALACTICA (IgdE) is a cysteine protease that digests human IgG1 at a specific site above the hinge, generating intact and homogeneous Fab and Fc fragments.
The enzyme facilitates the characterization of bi- and multispecific antibodies and analyses of intact and paired Fc glycosylation. It also simplifies the study of monovalent binding, higher order structures, disulfide scrambling and antibodies with mutated hinge regions.
Learn More About FabALACTICA
About GlySERIAS™
GlySERIAS is a unique enzyme that digests flexible glycine-rich fusion protein linkers such as Gly4Ser and GlyxSery (GS), and polyglycine (G) linkers.
The enzyme enables separation of the individual domains of multi-functional fusion proteins to facilitate characterization and increase the understanding of these molecules. Middle-level analysis of fusion proteins serves to both reduce the overall sample complexity and allows for domain-specific identification and monitoring of post-translational modifications.
Learn More About GlySERIAS