FabDELLO® for the Analysis of Hinge Mutated and Bispecific Antibodies

Novel Enzymatic Tools for Middle-level Analysis of Therapeutic mAbs with Hinge Mutations and Other New Modalities | ASMS (2022)

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FabDELLO® Lyophilized
Lyophilized enzyme for above hinge digestion of human IgG1

Complete Digestion of Mutates Antibodies and Fc-fusion Proteins using FabDELLO®
Performance Activity
Above-hinge digesiton of human IgG antibodies and Fc-fusion proteins, enabling robust characterization of engineered and hinge-mutated biotherapeutics.
Middle-level LC-MS Analysis of Mutated Antibodies using FabDELLO®
Application
Above hinge digestion at a single lysine residue, producing defined fragments for robust LC-MS analysis of LALA-engineered IgG1 antibodies.
Characterization of Bispecific Antibody Chain Pairing using FabDELLO®
Application
Improved characterization of bispecific antibody chain mispairing by FabDELLO subunit digestion and LC-MS resolution of Fab variants.