TransGLYCIT® to Evaluate Fc Effector Function of Therapeutic Antibodies

Fast and Robust Generation of Antibodies with Defined and Homogeneous Fc N-glycans | GlycoBioTec (2025)

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TransGLYCIT® Remodeling Afucosylated
Glycan remodeling of human IgG with the G0, G1, G2, G2S2 or Man5 glycoform, with core afucosylation.
TransGLYCIT® Remodeling
Glycan remodeling of human IgG with the G0, G1, G2 or G2S2 glycoform

Generation of IgG with G0 Glycan Profiles using TransGLYCIT®
Performance Activity
Simple and rapid generation of IgG with homogeneous G0F or G0 glycoforms for structural and functional characterization.
Generation of IgG with Galactosylated Glycan Profiles using TransGLYCIT®
Performance Activity
Rapid generation of galactosylated IgG with or without core fucose for structural and functional characterization.
Generation of IgG with Homegeneous Man5 Glycan Profiles using TransGLYCIT®
Performance Activity
Rapid and simple generation of IgG with defined Man5 glycoforms for structural and functional characterization.
Generation of IgG with Sialylated Fc-glycan Profiles using TransGLYCIT®
Performance Activity
Rapid generation of sialylated IgG Fc-glycan profiles, with or without core fucose, for structural and functional characterization.
Impact of Core Fucosylation on Antibody Effector Functions using TransGLYCIT®
Application
Functional comparison of antibody glycoforms by combining glycoengineering with ADCC and ADCP reporter assays to assess Fc effector activity.