LysCERATOR™
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LysCERATOR (Lys-C) is a lysine-specific endopeptidase that digests proteins C-terminally of lysine residues, including at lysine-proline linkages.
LysCERATOR Lyophilized is available as a lyophilized powder in vials of 20 μg enzyme.
Why LysCERATOR™ Lyophilized?
- Flexible format for method development
- Possible to combine enzymes for improved efficiency
- Amenable to automated workflows
- Ready to use – just add water!
Available Products
LysCERATOR™ Lyophilized 20 ug
Lyophilized enzyme for lysine-specific protein digestion. Processes 0.4-2 mg protein.
LysCERATOR™ Lyophilized 5 x 20 ug
Lyophilized enzyme for lysine-specific protein digestion. Processes 5 x 0.4-2 mg protein.
For information on how to order, visit Place an Order or contact us directly at order@genovis.com.
Product Information
Quality Control Assay
0.01 μg LysCERATOR Lyophilized digests ≥ 90% of 1 μg human IgG1 when incubated in 100 mM Tris pH 8.0 including 4 M Urea at 37°C, for 2 hours.
Buffers
LysCERATOR is optimally active in Tris and HEPES buffers in a pH range of 7.0 – 9.0. Activity is retained under denaturing conditions up to 8 M urea and 2 M guanidine hydrochloride.
Unit Defintion
LysCERATOR Lyophilized is supplied lyophilized in 50 mM HEPES, 100 mM NaCl, 2% trehalose, pH 8.5, with no preservatives added. It is shipped cold, and should be stored at -20°C upon arrival. After reconstitution, LysCERATOR Lyophilized is stable for 4 weeks at -20°C or for 1 week at +4-8°C.
Resources
Instruction for Use
Product Specifications
Safety Data Sheet
Certificate of Analysis
Find your certificate of analysis »Applications
Enhanced cleavage at challenging K–P sites, reducing missed cleavages and enabling more complete, confident peptide identification.
Superior digestion efficiency with high lysine specificity, generating more unique peptides for confident protein identification in complex proteomics workflows.
Efficient peptide mapping of antibodies with minimal missed cleavages and high sequence coverage for confident PTM identification.
Performance Activity
Consistent proteolytic activity delivered with no detectable autoproteolysis, enabling cleaner LC–MS data and more confident peptide identification.
High efficiency and peptide coverage maintained in strong denaturants, supporting analysis of highly structured and aggregation-prone proteins.
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