GlySERIAS®
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GlySERIAS is a unique enzyme that digests flexible glycine-rich fusion protein linkers such as Gly4Ser and GlyxSery (GS), and polyglycine (G) linkers.
GlySERIAS Lyophilized is available as a lyophilized powder in 2000 unit vials for digestion of 2 mg fusion proteins.
Why GlySERIAS® Lyophilized?
- Flexible format for method development
- Possible to combine enzymes for improved efficiency
- Amenable to automated workflows
- Ready to use – just add water!
- Enables linker characterization
Available Products
GlySERIAS® Lyophilized 2000 units
Lyophilized enzyme for digestion of 2 mg fusion protein
For information on how to order, visit Place an Order or contact us directly at order@genovis.com.
Product Information
Unit Defintion
One unit GlySERIAS digests ≥ 95% of 1 µg dulaglutide at a minimum of one site when incubated in TBS (50 mM Tris-HCl, 150 mM NaCl, pH 7.6) at 37°C for 15 minutes.
Content and Storage
GlySERIAS is supplied lyophilized in 50 mM Tris-HCl, 150 mM NaCl, pH 7.6, with no preservatives added. Upon arrival, the enzyme should be stored at -20°C. After reconstitution, GlySERIAS is stable for at least 1 month at +4-8°C.
Resources
Instruction for Use
Product Specifications
Safety Data Sheet
Certificate of Analysis
Find your certificate of analysis »AppNote GlySERIAS® for Digestion of Flexible Linkers of Fusion Proteins
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GlySERIAS® for LC-MS Analysis of Fusion Proteins with Flexible Linkers
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Applications
Robust and reproducible digestion of dulaglutide linkers, separating GLP-1 peptides from the Fc for domain-specific LC-MS analysis of protein modifications
GlySERIAS Immobilized delivers a more complete digestion of linkers for precise characterization of fusion protein quality attributes.
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