AppNote SmartEnzymes™ for mAb Oxidation

A Rapid LC-MS Assay for Monitoring of mAb Oxidation at the Subunit Level

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GlycINATOR™ Lyophilized
Lyophilized enzyme for hydrolysis of all types of Fc N-glycans
FabRICATOR® Lyophilized
Lyophilized enzyme for below hinge digestion of IgG

Rapid Determination of Fc Oxidation using FabRICATOR® and GlycINATOR™
Application
Fast and reliable middle-level analysis of antibody oxidation using FabRICATOR and GlycINATOR, supporting robust QC of critical quality attributes.
Mode-of-Action Study of Deglycosylated Antibodies using GlycINATOR™
Application
Removal of Fc N-glycans abolishes ADCC activity, enabling direct study of glycan-mediated Fc receptor interactions and antibody function.
Fc N-glycan Hydrolysis for Afucosylation Assessment using GlycINATOR™
Application
A simple and rapid estimation of IgG core fucosylation and glycan occupancy using LC-MS analysis.