GlycINATOR™
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GlycINATOR™ Lyophilized
Lyophilized enzyme for hydrolysis of all types of Fc N-glycans
GlycINATOR (EndoS2) is an IgG-specific endoglycosidase that hydrolyzes all glycoforms present at the Fc N-glycosylation sites.
GlycINATOR Lyophilized is available as a lyophilized powder in 2000 unit vials for deglycosylation of 2 mg IgG.
Why GlycINATOR™ Lyophilized?
- Flexible format for method development
- Possible to combine enzymes for improved efficiency
- Amenable to automated workflows
- Ready to use – just add water!
Available Products
GlycINATOR Lyophilized 2000 units
Lyophilized enzyme for deglycosylation of 2 mg IgG
For information on how to order, visit Place an Order or contact us directly at order@genovis.com.
Product Information
Unit Defintion
One unit deglycosylates ≥ 95% of 1 μg human IgG when incubated in 10 mM sodium phosphate, 150 mM NaCl, pH 7.4 at 37°C for 30 min.
Content and Storage
GlycINATOR Lyophilized is reconstituted by addition of water. No preservatives added. After reconstitution, the enzyme is stable for 1 month at +4-8°C. The product is shipped at ambient temperature, and should be stored at -20°C upon arrival.
Resources
Instruction for Use
Product Specifications
Safety Data Sheet
Certificate of Analysis
Find your certificate of analysis »AppNote SmartEnzymes™ for mAb Oxidation
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Applications
Fast and reliable middle-level analysis of antibody oxidation using FabRICATOR and GlycINATOR, supporting robust QC of critical quality attributes.
Removal of Fc N-glycans abolishes ADCC activity, enabling direct study of glycan-mediated Fc receptor interactions and antibody function.
A simple and rapid estimation of IgG core fucosylation and glycan occupancy using LC-MS analysis.
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