FabRICATOR® Xtra
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FabRICATOR® Xtra LALA Lyophilized
Lyophilized enzyme for below hinge digestion of hinge-mutated IgG, including LALA
FabRICATOR Xtra LALA is an IgG-specific protease that digests antibodies which have been engineered to contain mutated hinges, including the LALA mutation. It digests below the hinge, generating F(ab’)2 and Fc fragments.
FabRICATOR Xtra LALA Lyophilized is available as a lyophilized powder in 2000 unit vials for digestion of up to 2 mg hinge-mutated IgG.
Why FabRICATOR® Xtra LALA Lyophilized?
- Flexible format for method development
- Possible to combine enzymes for improved efficiency
- Amenable to automated workflows
- Ready to use – just add water!
Available Products
FabRICATOR® Xtra LALA Lyophilized 2000 units
Lyophilized enzyme for below hinge digestion of up to 2 mg of hinge-mutated IgG
For information on how to order, visit Place an Order or contact us directly at order@genovis.com.
Product Information
Unit Defintion
One unit FabRICATOR Xtra LALA Lyophilized digests ≥ 95% of 1 µg human IgG1-LALA (L234A, L235A) when incubated in 10 mM sodium phosphate, 137 mM NaCl, 2.7 mM KCl, pH 7.4 at 37°C for 1 hour.
Content and Storage
FabRICATOR Xtra LALA Lyophilized is reconstituted by addition of water. No preservatives added. After reconstitution, the enzyme is stable for 1 month at +4-8°C. The product is shipped cold and should be stored at -20°C upon arrival.
Resources
Instruction for Use
Product Specifications
Safety Data Sheet
Certificate of Analysis
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Efficient digestion of hinge-mutated antibodies, generating fragments for comprehensive subunit LC-MS analysis of engineered IgG formats
FAQ and Support
Are there any mutated IgG formats that FabRICATOR Xtra LALA cannot digest?
Yes, of the formats we have specifically tested, hIgG1-LALAPG (L234A, L235A, P329G), hIgG1-STR (L234S, L235T, G236R) and hIgG1-L234F, L235E, D265A could not be digested to satisfactory levels using FabRICATOR Xtra LALA. Please refer to footnote 4 in the instructions for use to determine whether your antibody is likely to be suitable for FabRICATOR Xtra LALA digestion.
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Genovis products are intended for research use only. They are not intended to be used for therapeutic or diagnostic purposes in humans or animals. All goods and services are sold subject to Genovis’ General Terms and Conditions of Sale.
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