Tell us about your project!
We are working on the glycan engineering of mucin by SmartEnzymes, specifically the SialEXO enzyme. The abundant glycans on mucin are the bioactive ligands binding to biomolecules and cell receptors, modulating cell responses and human physiology.
How did SmartEnzymes enhance your project?
SialEXO is one of the most efficient sialidases we tested that can remove sialic acid from mucin in mucus gel directly. This high activity enhances our aim to modulate the cell responses towards modified mucin in mucus, with potential application as new therapy for mucin-related diseases.
