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We are excited to announce the speaker and topic for our next GenovisWebinar!
FabRICATOR® (IdeS) is an established tool for middle-level subunit analysis of monoclonal antibodies (mAbs). It is an IgG-specific cysteine protease that digests antibodies at a single amino acid site below the hinge, generating homogenous F(ab’)2 and Fc fragments. It offers several advantages over intact analysis and subunit analysis using reduction only. It is less cumbersome to perform than peptide mapping, all while delivering comparable details on mAb post-translational modifications (PTMs).
In this webinar, we are happy to invite Olle de Bruin from BioInvent International to provide examples of how FabRICATOR subunit analysis supports clone selection during process development, allowing for quick and easy characterization of product quality in order to make more informed decisions. In addition, to simplify and speed-up the mAb characterization workflow, Olle shows that LC-MS subunit analysis can be accomplished directly from culture supernatants using FabRICATOR without the need for time-consuming affinity purification.
Title: “Subunit Analysis of mAbs to Support Process Development and Clone Selection”
Date: October 19th, 2023
Time: 4 pm CET
REGISTER HERE!
Key Learning Objectives
- Using FabRICATOR, mAb subunit analysis is possible without antibody purification
- Subunit analysis can provide details on mAb PTMs directly from culture supernatant, which intact analysis is not capable of
- BioInvent is a clinical-stage company that discovers and develops antibodies for cancer therapy
- BioInvent offers mAb production from cell line development to manufacturing
Who Should Attend?
- Scientists involved in cell-line development (CLD) activities
- Scientists involved in the MS characterization of biopharmaceuticals
- Scientists performing middle-level analysis of mAbs
- Contract Research Organizations (CROs)
- Contract Manufacturing Organizations (CMOs)
- Academic scientists working with protein characterization by MS
About FabRICATOR®
FabRICATOR (IdeS) is an IgG-specific cysteine protease that digests antibodies at a single amino acid site below the hinge, generating homogenous F(ab’)2 and Fc fragments.
The enzyme is widely used in characterization, quality control, stability testing, production monitoring and clone selection of antibody-based therapeutics such as mAbs, ADCs, biosimilars and Fc-fusion proteins.
Learn More About FabRICATOR