Articles by Sylvia Koivunen

Real-time Monitoring of Antibody Quality Control using FabRICATOR

September 23, 2015 | Applications, References |

The production of antibody-based therapeutics requires careful monitoring of quality attributes. Researchers at Amgen developed a technology to model and monitor the high-mannose content of the antibody in real-time using FabRICATOR digestion (Zupke et al. 2015). Read more »

Study of Antibody Quality Attributes on Cell Culture Supernatant

September 23, 2015 | Applications, References |

The production of antibody-based therapeutics requires careful monitoring of quality attributes. Researchers at Institute Pasteur in collaboration with LFB Biotechnologies have used FabRICATOR to monitor important quality attributes of a therapeutic antibody, directly on the cell culture supernatant (Henninot et al. 2015).
Read more »

Now Available – FragIT™Z & FragIT™Z Kit

May 28, 2015 | Products |

We like to introduce FragIT Z – the immobilized version of FabRICATOR Z. Digest your mouse IgG2a more rapidly without having to remove the enzyme from the final preparation.

For separation of the generated antibody domains we also offer the convenient FragIT Z Kit which enables rapid isolation of F(ab’)2 and Fc.

Read more about these products here

Genovis Enzyme Reference Tool

May 28, 2015 | References |

Our enzymes are used frequently for studying important quality attributes of antibody-based biotherapeutics.

To help you find the reference of interest we developed an Enzyme Reference Tool that organizes all papers published using our products. With this tool you can filter by quality attribute, enzyme used, type of antibody molecule and technology.

Follow this link and try it out

Introducing FabRICATOR Z for mouse IgG2a

May 5, 2015 | Products |

We are proud to present a new member of the SmartEnzyme family: FabRICATOR Z (IdeZ).

FabRICATOR Z (IdeZ) is a cystein protease highly similar to FabRICATOR (IdeS). However, FabRCATOR Z is much more efficient in digesting mouse IgG2a and IgG3 than FabRICATOR. The new enzyme is as easy to use as “regular” FabRICATOR – add the enzyme to your mouse IgG and incubate 2 hours to get a homogenous pool of F(ab’)2 and Fc-fragments.

Read more about FabRICATOR Z here