Selective enrichment of IgA O-glycopeptides for improved detection and characterization of hinge-region glycosylation.
O-glycan Mapping
O-glycan mapping supports the identification of O-glycan sites and characterization of glycans attached to proteins via O-linkages. This analysis is important for understanding protein function and evaluating heterogeneity. Our solutions support precise and reproducible workflows, helping you generate detailed O-glycan profiles.
Applications
Simple and direct O-glycan site identification by site-specific digestion, generating fragments which can be used for high-resolution middle-level analysis.
Precise O-glycan site mapping by generating small, MS-friendly O-glycopeptides and improved confidence through overlapping sequence coverage.
Broad O-glycan substrate acceptance efficiently generating informative O-glycopeptides while retaining glycan structure information.
Combining multiple digestions for O-glycan site mapping with glycan structure analysis for complete characterization of heavily O-glycosylated proteins.
Resources
How OpeRATOR™ Works
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AppNote OpeRATOR™ for Determination of O-glycan Sites
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AppNote OpeRATOR™ for Automated O-glycopeptide Profile Monitoring
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SmartEnzymes™ Brochure
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SmartEnzymes™ for O-glycosylation Analysis using Mass Spectrometry
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SmartEnzymes™ for O-glycosylation Analysis using LC-MS
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