Removal of Fc N-glycans abolishes ADCC activity, enabling direct study of glycan-mediated Fc receptor interactions and antibody function.
Functional assays
Functional assays measure the biological activity of a molecule by assessing its effect on cells or biological systems. They are essential for understanding mechanism of action and potency. Our solutions support consistent and robust assay performance, helping you generate reliable and meaningful functional data.
Applications
Functional comparison of antibody glycoforms by combining glycoengineering with ADCC and ADCP reporter assays to assess Fc effector activity.
Resources
TransGLYCIT®
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TransGLYCIT® for Fc-specific N-glycan Remodeling of Human IgG
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