Why Outsourcing Your Antibody Services Could Be the Smartest Move You Make This Year
In biopharmaceutical research, antibody quality is everything. Whether you’re developing an antibody-drug conjugate (ADC), studying glycan-mediated effector function, or characterizing a therapeutic candidate, the precision and reliability of your antibody workflow directly impacts your results – and your timeline.
But setting up and optimizing these workflows in-house takes significant time, resources, and specialized expertise. That’s where Genovis Services comes in.
Expertise You Can Rely On
At Genovis, we’ve spent years developing SmartEnzymes™ – highly specific, efficient enzymes that enable precise antibody modification and characterization. Now, that same technology and expertise is available to you as a service.
Our team of scientists handles everything from sample receipt to final report, with rigorous quality control at every step. The result: reliable, reproducible data you can trust.
What We Can Do for You
Antibody Conjugation – Homogeneous Conjugates, Every Time
Random conjugation introduces variability that can compromise your results. Our Antibody Conjugation service uses GlyCLICK®, a technology that enables site-specific conjugation at the Fc N-glycan sites, delivering a precise drug-antibody ratio (DAR) of 2. This controlled conjugation preserves antigen-binding capacity and stability – critical for ADC development and other functional applications.
Every step of the GlyCLICK workflow is monitored using middle-level LC-MS, giving you complete visibility into the conjugation process. You receive the conjugated material together with a detailed analysis report. Turnaround: 2-4 weeks.
Antibody Glycan Remodeling – Control Your Glycan Profile
Glycosylation profoundly influences antibody effector function, pharmacokinetics, and immunogenicity. Our Antibody Glycan Remodeling service uses TransGLYCIT® technology to replace native Fc N-glycans with a defined glycan of your choice – G0, G1, G2, G2S2, or Man5 – with the option to retain or remove the core fucose.
This service is particularly valuable for researchers investigating glycan-function relationships or developing next-generation biologics with tailored effector profiles. Feasibility studies are available to optimize the workflow for your specific sample. Turnaround: typically 4 weeks.
Antibody DOL Determination – Know Your Conjugation Efficiency
Degree of labeling (DOL) is a critical quality attribute for any conjugated antibody. Our high-resolution LC-MS service provides both average DOL and DOL distribution, giving you a complete picture of your conjugate quality. With minimal sample preparation required and results delivered within 5 working days, it’s one of the fastest ways to validate your conjugation outcome.
Antibody LC-MS Analysis – Quality Data, Fast
Understanding your antibody’s critical quality attributes doesn’t have to take weeks. Our LC-MS Analysis service provides comprehensive profiling – including glycosylation profile, mass confirmation, afucosylation, high-mannose content, C-terminal lysine, and N-terminal pyroglutamate – in an easy-to-interpret report, within 5 working days. It’s the kind of data that typically takes significant in-house resource to generate. We make it accessible.
Antibody Fragmentation – From Whole IgG to Defined Fragments
Sometimes you need the fragment, not the whole antibody. Our Fragmentation service generates Fab, F(ab’)₂, and Fc fragments using SmartEnzymes, with purification and LC-MS characterization included as standard. Whether you need fragments for structural studies or downstream applications, we tailor the workflow to your sample and desired outcome. Turnaround: typically 2-4 weeks.
The Genovis Approach: Tailored, Transparent, Reliable
Every service starts with a conversation. We work with you to understand your sample, your goals, and your timeline – then we provide a detailed service proposal before work begins. Throughout the process, you’re kept informed with data at every step.
When we deliver, you receive more than just conjugated material or analysis data. You receive a comprehensive report that gives you the full picture – and the confidence to move forward.
Ready to Get Started?
Whether you’re working on an ADC program, optimizing a biologic candidate, or simply need reliable antibody characterization data, we’re here to support you!
Visit www.genovis.com/services to learn more about each service, or contact our team directly to discuss your project.
We’d love to help you move forward – with confidence.