GlyCLICK® ADC

Site-specific conjugation of IgG with MMAE or PNU

Available Products

  • ADC

GlyCLICK is a three-step conjugation technology for site-specific and quantitative conjugation of IgG from several species and subclasses.

GlyCLICK ADC is available for site-specific labeling of 2 mg IgG with MMAE (Monomethyl auristatin E) or PNU (PNU anthracycline payload), and is suitable for the development of antibody-drug conjugates (ADCs).

MMAE is a potent cytotoxin that inhibits microtubule assembly and tubulin-dependent GTP hydrolysis, causing cell cycle arrest and apoptosis.
PNU is an anthracycline based DNA-alkylating toxin causing apoptosis with significantly higher potency that tubulin-targeting payloads.

Why GlyCLICK® ADC?

  • Site-specific payload-conjugation to IgG with a consistent drug-antibody ratio (DAR) of 2
  • Unique linker payloads with a two-step enzymatic release mechanism
  • Generates a site-specific ADC without antibody engineering
  • Preserved immunoreactivity with greater control of cytotoxicity

Available Products

  • GlyCLICK® ADC MMAE 2 mg

    Site-specific conjugation of 2 mg IgG with MMAE

    L1-T02-200

    €2,369.00

    Buy / Request a Quote

    • GlyCLICK® ADC PNU 2 mg

      Site-specific conjugation of 2 mg IgG with PNU

      L1-T01-200

      €2,690.00

      Buy / Request a Quote

      For information on how to order, visit Place an Order or contact us directly at order@genovis.com.

      Product Information

      Unit Defintion

      GlyCLICK ADC contains sufficient material for labeling of 2 mg IgG. For larger amounts or evaluation of the technology, please contact us.

      Contents

      Components in GlyCLICK ADC:

      • GlycINATOR Immobilized
      • UDP-GalNAz
      • GalT(Y289L)
      • sDIBO (MMAE or PNU)
      • All buffers needed
      • Concentration and desalting columns

      Storage

      The components of GlyCLICK ADC should be stored at different temperatures upon arrival.

      Resources

      Applications

      Legal & Disclaimers

      All rights reserved. Genovis products may be covered by one or more patents, trademarks and copyrights owned by Genovis AB or licensed from third parties. For more information about commercial rights, please contact the Genovis team at licensing@genovis.com.

      Genovis products are intended for research use only. They are not intended to be used for therapeutic or diagnostic purposes in humans or animals. All goods and services are sold subject to Genovis’ General Terms and Conditions of Sale.

      SiteClick™ included in GlyCLICK®
      This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. The trademark SiteClick™ is the property of Life Technologies Corporation.

      Linker-toxin Payloads included in GlyCLICK® ADC
      This product is provided under an intellectual property license from Glykos Finland ltd. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer. The buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; or (b) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research.

      © Genovis AB

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