Where does FabRICATOR cleave the IgG molecule?

FabRICATOR® cleave the IgG molecule in one specific site in the lower hinge region of the anitbody leaving a F(ab’)2 fragment and a Fc-fragment.
Human IgG1:  ..CPAPELLG / GPSVF..
Human IgG2:  ..CPAPPVA / GPSVF..
Human IgG3:  ..CPAPELLG / GPSVF..
Human IgG4:  ..CPAPEFLG / GPSVF..

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