GingisKHAN™ Fab Kit 2 mg
Lyophilized enzyme and affinity resin for above hinge digestion of 2 mg human IgG1 and purification of fragments
GingisKHAN (Kgp) is a cysteine protease that digests human IgG1 at a single site above the hinge, generating intact and homogenous Fab and Fc fragments.
Lyophilized GingisKHAN (KGP) for digestion of 2 mg of human IgG1 together with 5 vials of lyophilized GingisKHAN reducing agent and four CH1 micro spin columns where each column includes sufficient material to purify up to 0.5 mg IgG.
GingisKHAN (KGP) is a unique protease that cleaves human IgG1 at one single amino acid position just above the hinge region generating intact Fc and Fab fragments.
The enzyme require very mild reducing reaction conditions and for conveniece and reliable performance, the product is provided with 5 vials of lyophilized GingisKHAN reducin agent. The enzyme and reduciton agent are reconstituted by addition of water.
The CH1 affinity matrix recognizes the CH1 domain of human IgG antibodies, which enables purification of Fab fragments, independent of the light-chain isotype and source material. Due to its unique selectivity for the CH1 domain, no co-purification of free light-chain contaminants will occur.
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