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Product Information

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Instructions

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Specifications

Specifications for every Genovis product

Certificate of Analysis

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Product Information

All SmartEnzymes

All products

GlySERIAS

OmniGLYZOR

TransGLYCIT

FabDELLO

PNGase F

GlyCLICK

Application Notes

Videos

FabRICATOR

FabRICATOR (IdeS) is a cysteine protease that digests antibodies at a specific site below the hinge, generating a homogenous pool of F(ab')2 and Fc/2 fragments. Watch the movie of how FabRICATOR works here.

GlyCLICK

GlyCLICK is a site-specific conjugation technology for IgG using enzymatic remodeling of the Fc-glycans and click-chemistry. It facilitates site-specific labeling of antibodies in a range of applications, for example imaging and ADC development. Watch the movie of how GlyCLICK works here.

OpeRATOR

OpeRATOR is an O-glycan specific protease that digests proteins carrying mucin-type O-glycans N-terminally of serine and threonine glycosylation sites. Watch the movie of how OpeRATOR works here.

FabRICATOR® MagIC

Dan Bach Kristensen from Symphogen A/S presents an evaluation of FabRICATOR MagIC for automated digestion of antibodies and middle-level analysis of complex antibody mixtures. Watch the entire presentation here.

Posters

TransGLYCIT

Fast and Efficient Evaluation of the Impact of Fc N-glycosylation on Antibody-dependent Cellular Cytotoxicity
AET Europe, 2022

FabRICATOR / GlycINATOR

A Rapid, Automated LC-MS Assay for Analysis of Methionine Oxidation in Therapeutic mAbs
CASSS MS, 2021

GlyCLICK

Site-specific Antibody Drug Conjugation with 2-step Cleavable Linker-payloads Displays Potent In Vivo Efficacy
World ADC, 2021

GalNAcEXO

New Enzymatic Strategies for Probing N- and O-glycans on Biopharmaceuticals.
FoB, 2020

FabDELLO

Novel Enzymatic Tools for Middle-level Analysis of Therapeutic mAbs with Hinge Mutations and Other New Modalities
ASMS, 2022

OpeRATOR

In-depth LC-MS Analysis of O-glycosylated Biopharmaceuticals Using an O-glycan Specific Endoprotease
CASSS MS, 2019

OglyZOR, SialEXO

Complete N- and O-Deglycosylation of Biopharmaceuticals
PEGS, 2019

FabRICATOR-HPLC

An Automated Workflow for Analysis of Monoclonal Antibody Subunits
Analytical Technologies Europe (CASSS), 2019

GlycINATOR

Therapeutic Antibodies Trimmed with GlycINATOR® Loses Antibody-Dependent Cell-mediated Cytotoxicity
Antibody Industrial Symposium, 2018

Immobilized SialEXO

Complete and Rapid Desialylation of Therapeutic Glycoproteins using Immobilized SialEXO
Antibody Engineering & Therapeutics, 2019

TransGLYCIT

Fast and Efficient Evaluation of the Impact of Fc N-glycosylation on Antibody-dependent Cellular Cytotoxicity
AET Europe, 2022

Fc-Specific N-glycan Remodeling of Human IgG
Festival of Biologics US, 2022

Fc-Specific N-glycan Remodeling of Human IgG
GlycoNET, 2021

GlyCLICK

Site-specific Antibody Drug Conjugation with 2-step Cleavable Linker-payloads Displays Potent In Vivo Efficacy
World ADC, 2021

Robust Generation of Site-specific and Homogeneous Antibody Conjugates using GlyCLICK®
World ADC, 2019

GlyCLICK Generates Homogeneous Antibody Conjugates with Preserved Affinity
World ADC, 2018

Site-specific Conjugation of Antibodies using GlyCLICK^® Results in Homogenous Conjugates, Preserved Antigen Binding, and Increased Tumor Uptake In Vivo
Antibody Engineering, 2017

OpeRATOR

In-depth LC-MS Analysis of O-glycosylated Biopharmaceuticals Using an O-glycan Specific Endoprotease
CASSS MS 2019

Analysis of O-glycosylated Biopharmaceuticals using an O-glycan Dependent Endoprotease and LC-MS
ASMS 2019

An O-glycan Specific Endoprotease with Applications in Glycoprotein Analysis using LC-MS
PEGS 2018

Site-specific O-glycan Analysis using a Novel O-glycan Protease and LC-MS/MS
PEGS Summit Europe, 2017

OpeRATOR and GlycOCATCH

A Novel O-glycoprotease with Applications in O-glycan Analysis using Mass Spectrometry
ASMS, 2018

FabDELLO

Novel Enzymatic Tools for Middle-level Analysis of Therapeutic mAbs with Hinge Mutations and Other New Modalities
ASMS, 2022

FabRICATOR / GlycINATOR

A Rapid, Automated LC-MS Assay for Analysis of Methionine Oxidation in Therapeutic mAbs
CASSS MS, 2021

FabRICATOR-HPLC

An Automated Workflow for Analysis of Monoclonal Antibody Subunits
Analytical Technologies Europe (CASSS), 2019

Rapid On-column Digestion for Automated Monoclonal Antibody Analysis
PEGS 2018

FabALACTICA (IgdE)

FabALACTICA Generates Pure and Homogeneous mAb Subunits that Facilitate 2D-NMR Spectroscopy Analysis
Festival of Biologics, 2019

Preparation of Pure Antibody Fab Fragments Using a Robust and Specific Enzyme (IgdE)
Analytical Technologies Europe (CASSS), 2017 and PEGS US, 2017

OpeRATOR, OglyZOR, SialEXO

Novel Enzymes for O-glycan Analysis
Analytical Technologies Europe (CASSS) 2018

OglyZOR, SialEXO

Complete N- and O-Deglycosylation of Biopharmaceuticals
PEGS, 2019

GlycINATOR

Therapeutic Antibodies Trimmed with GlycINATOR® Loses Antibody-Dependent Cell-mediated Cytotoxicity
Antibody Industrial Symposium, 2018

GingisREX (RgpB)

RgpB – an Arginine Specific Protease with Applications in Proteomics
Analytical Technologies Europe (CASSS), 2016 and US HUPO, 2016

FabRICATOR in Middle-Down MS

Optimizing the Enzymatic Subunit Generation with IdeS for High Throughput Structure Verification of Therapeutic Antibodies by Middle-Down Mass Spectrometry
ASMS, 2013

GingisKHAN (KGP)

Initial Characterization of a Novel Cysteine Protease for Antibody Sub Unit Analysis
Analytical Technologies Europe (CASSS), 2014

SmartEnzymes & HPLC

Rapid and Simple Determination of PTMs in Monoclonal Antibodies using an Enzymatic HPLC Approach
Biotherapeutics Analytical Summit, 2014

SmartEnzymes for Rapid LC/MS

Highly Specific Enzymes for Rapid LC/MS Analysis of Therapeutic Antibody Products
ASMS, 2014

FabULOUS (SpeB)

Initial Characterization of a Recombinantly Modified SpeB from S. pyogenes for Antibody Subunit Domain Generation
CASSS, 2013

Instructions

FabRICATOR (English)
FabRICATOR (Chinese)

Antibody Digestion

FabALACTICA^®

FabALACTICA 2000 units
Immobilized FabALACTICA Microspin
Immobilized FabALACTICA Midispin
Immobilized FabALACTICA Maxispin
FabALACTICA Fab kit Microspin
FabALACTICA Fab kit Midispin
FabALACTICA Fab kit Maxispin

FabDELLO^™

FabDELLO

FabRICATOR^®

FabRICATOR (English)
FabRICATOR (Chinese)
FragIT Micro-, Midi-, Maxispin
FragIT kit Micro-, Midi-, Maxispin
FabRICATOR LE 2000 and 5000 units
FabRICATOR-HPLC
FabRICATOR MagIC

FabRICATOR^® Z

FabRICATOR Z 2000 units
FragIT Z
FragIT Z Kit

FabULOUS^™

FabULOUS 2000 units
FabULOUS Fab kit mouse

GingisKHAN^®

GingisKHAN 2000 units
GingisKHAN Fab kit

GlySERIAS^™

GlySERIAS, 2000 units

Antibody Deglycosylation

GlycINATOR^®

GlycINATOR 2000 units
GlycINATOR LE 2000 units
Immobilized GlycINATOR Micro-, Midi-, Maxispin

IgGZERO^®

IgGZERO 1000 and 5000 units
IgGZERO LE 2000 units
deGlycIT Micro-, Midi-, Maxispin

Antibody Conjugation

GlyCLICK^®

GlyCLICK labeling kit 250 μg (AlexaFluor®488, AlexaFluor®555, AlexaFluor®647, Biotin, DFO)
GlyCLICK labeling kit 2 mg (AlexaFluor®488, AlexaFluor®555, AlexaFluor®647, Biotin, DFO)
GlyCLICK ADC kit 2mg (MMAE PNU)
GlyCLICK Azide Activation 250 μg
GlyCLICK Azide Activation 2 mg
GlyCLICK Azide Activation 10 mg

TransGLYCIT^™

TransGLYCIT, 1 mg
TransGLYCIT Afucosylated, 1 mg
TransGLYCIT Azide Activation, 100 μg
TransGLYCIT Azide Activation hIgG2, 100 μg

Proteomics

GingisREX^®

GingisREX

Glycan Profiling

FucosEXO^™

FucosEXO 2000 units
Immobilized FucosEXO

GalactEXO^®

GalactEXO 2000 units
Immobilized GalactEXO

GalNAcEXO™

GalNAcEXO 2000 units
Immobilized GalNAcEXO

OglyZOR^®

OglyZOR 2000 units