SmartEnzymes™
Antibody Deglycosylation
GlycINATOR® (EndoS2)
Hydrolysis of all Fc N-glycans
IgGZERO® (EndoS)
Hydrolysis of Fc N-glycans
Reduce Sample Heterogeneity
The IgG-specific glycosidases trim IgG Fc-glycoforms on native antibodies, including high-mannose, hybrid, complex, and bisecting type glycans. The enzymes are used to reduce the complexity of antibody-based therapeutics and to study core afucosylation and N-glycan site occupancy.