Antibody Deglycosylation

GlycINATOR® (EndoS2)

Hydrolysis of all Fc N-glycans

IgGZERO® (EndoS)

Hydrolysis of Fc N-glycans

Reduce Sample Heterogeneity

The IgG-specific glycosidases trim IgG Fc-glycoforms on native antibodies, including high-mannose, hybrid, complex, and bisecting type glycans. The enzymes are used to reduce the complexity of antibody-based therapeutics and to study core afucosylation and N-glycan site occupancy.

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