Antibody Conjugation

Transglycosylation and Conjugation of IgG

The GlyCLICK technology is a platform for site-specific labeling at the Fc N-glycan sites of native IgG, and it consists of enzymatic glycan remodeling and click chemistry. The technology is available in a range of kit formats, including conjugation with fluorophores, biotin, DFO, or toxins for ADC development. The format "Azide Activation" renders the antibody azide-activated, for conjugation with any alkyne-reactive label of choice (DOL=2).

TransGLYCIT is a platform that enables efficient and site-specific human IgG glycan remodeling. With TransGLYCIT, antibodies with defined and homogenous glycoforms are generated using fast and robust enzymatic workflows. The Remodeling formats facilitate functional analysis of specific glycan structures.