A New Standard in Lys-C Digestion: Introducing LysCERATOR™
Efficient Lys-C digestion is critical for reliable protein identification in modern proteomics workflows. Missed cleavages, incomplete protein digestion, and challenging sample types can quickly reduce confidence in downstream LC–MS analysis. To address these challenges, Genovis has launched LysCERATOR™, a new Lys-C enzyme for efficient, lysine-specific protein digestion — even under demanding conditions.
LysCERATOR delivers best-in-class digestion efficiency at lysine residues, minimizing missed cleavages and supporting cleaner peptide generation. In complex samples such as HeLa cell lysates, LysCERATOR generated more unique peptides and a higher proportion of fully digested peptides compared with alternative Lys-C enzymes. This results in a more informative peptide pool and improved confidence in LC–MS-based protein analysis.
Challenging lysine–proline (K–P) linkages are a well-known limitation in traditional Lys-C digestion. In trastuzumab digestion experiments, LysCERATOR demonstrated superior cleavage at K–P sites, achieving more complete protein digestion and fewer missed cleavages than alternative Lys-C enzymes.
Well suited for modern proteomics workflows, LysCERATOR retains high activity under strong denaturing conditions. This robustness supports efficient protein digestion when denaturants are required for effective protein solubilization, making LysCERATOR™ suitable for a wide range of sample types and proteomics applications.
Together, these performance characteristics define what we mean by a new standard in Lys-C digestion — combining high digestion efficiency, robustness in complex samples, and reliable cleavage at challenging sites to support confident protein identification.
If you’re exploring improved Lys-C digestion for your proteomics workflow, detailed product information is available, including the product folder, specifications, and instructions for use.
👉 Discover LysCERATOR™