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ASMS is always an exciting opportunity to discover new science and innovative mass spectrometry workflows. Throughout the meeting, researchers from around the world will present posters and oral presentations featuring workflows supported by Genovis SmartEnzymes™. In this year’s Digested Guide to ASMS, we’ve gathered selected presentations and posters we’re especially excited to follow. We hope…
Efficient Lys-C digestion is critical for reliable protein identification in modern proteomics workflows. Missed cleavages, incomplete protein digestion, and challenging sample types can quickly reduce confidence in downstream LC–MS analysis. To address these challenges, Genovis has launched LysCERATOR™, a new Lys-C enzyme for efficient, lysine-specific protein digestion — even under demanding conditions.
A new preprint from the creators of FLASH-seq demonstrates that replacing protein-based RNase inhibitors with the synthetic, thermostable SEQURNA significantly improves sensitivity, especially in low-RNA cells, while enabling a fully DTT-free workflow.
In molecular biology, temperature control is one of those quiet essentials that makes all the difference. From snap-freezing delicate RNA to gently warming enzyme reactions, the right temperature brings consistency to every result. Thermoconductive modules have anchored molecular biology labs for years, replacing ice buckets and uneven heat blocks with stable, uniform temperature control. But…
Researchers at Roche have recently described an elegant solution to address the persistent problem of rheumatoid interference (RF) in anti-drug antibody (ADA) immunoassays. IgMBRAZOR is a unique IgM-specific protease that digests human IgM at one specific site below the CH2 domain in the heavy chain, generating homogeneous F(ab’)2 and Fc fragments. By introducing IgMBRAZOR pretreatment…
Scientists at Boehringer Ingelheim and collaborators have developed a novel method to generate antibodies with defined asymmetrical Fc glycoforms and evaluate their Fc receptor (FcγRs) binding properties. Combining enzymatic digestion and redox-mediated Fc recombination, Fc fragments with specific glycan pairings could be generated and their Fc receptor binding analyzed by surface plasmon resonance (SPR) spectroscopy.
Preserving RNA integrity is essential in molecular biology workflows, and RNase inhibitors are a critical part of that process. But if you're still relying on a traditional protein-based recombinant inhibitor, it could be costing you more than you think - in both performance and budget. Here's why it's time to switch to a smarter alternative:
Scientists at New Jersey Institute of Technology, Johnson & Johnson and collaborators have demonstrated a novel approach for mass spectrometry (MS)-based characterization of hinge-mutated antibodies. Combining the recently introduced FabRICATOR Xtra LALA enzyme with ultrafast microdroplet digestion allows for fully automated, high-throughput and efficient antibody characterization, with the entire sample preparation and MS analysis completed…
Scientists at Biogen have developed an approach to better understand monoclonal antibody (mAb) aggregation by characterizing fragments that may form during the production process. Fab/c fragments – common impurities generated through hinge digestion and loss of a Fab subunit – can offer valuable insights into aggregation mechanisms. To support this work, FabALACTICA, which specifically digests…
Scientists at Aalen University and their collaborator present a detailed methodology for the rapid and thorough characterization of monoclonal antibody (mAb) variants using capillary electrophoresis-mass spectrometry (CE-MS) at the subunit level. mAbs are an important class of therapeutic molecules for treating various diseases, including cancer and autoimmune disorders. mAbs are large, complex molecules and can…
Scientists at The Finsen Laboratory and collaborators have described the potential for a novel antibody-drug conjugate (ADC) to treat pancreatic ductal adenocarcinoma (PDAC). The ADC candidate is conjugated with a highly potent anthracycline payload (PNU-159682) using GlyCLICK conjugation technology, and targets uPAR (urokinase plasminogen activator receptor), a protein overexpressed in PDAC and its surrounding stroma.…
On this Nobel Day, we honor two monumental breakthroughs in RNA research recognized by the Nobel Prize in Physiology or Medicine! 🏆
