Removal of N- and O-glycans from complex and heavily glycosylated proteins, enables clear, interpretable LC-MS analysis.
Applications
Explore how our solutions are used across a range of applications. From sample preparation to advanced analysis, you can find insights into how they support different workflows and help address common challenges.
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Consistent proteolytic activity delivered with no detectable autoproteolysis, enabling cleaner LC–MS data and more confident peptide identification.
Efficient peptide mapping of antibodies with minimal missed cleavages and high sequence coverage for confident PTM identification.
Superior digestion efficiency with high lysine specificity, generating more unique peptides for confident protein identification in complex proteomics workflows.
Native removal of O-glycans and removal of inaccessible N-glycans under denaturing conditions, enables complete glycan analysis of the complex C1-inhibitor
Robust and reproducible digestion of dulaglutide linkers, separating GLP-1 peptides from the Fc for domain-specific LC-MS analysis of protein modifications
Efficient digestion of multi-domain BiTE molecules, separating the domains for high-quality LC-MS analysis and precise localization of protein modifications
Efficient digestion of hinge-mutated antibodies, generating fragments for comprehensive subunit LC-MS analysis of engineered IgG formats
Efficient analysis of bispecific antibodies, enabling accurate assessment of chain pairing and assembly in Fc-engineered antibody formats
Enhanced cleavage at challenging K–P sites, reducing missed cleavages and enabling more complete, confident peptide identification.
