High efficiency and peptide coverage maintained in strong denaturants, supporting analysis of highly structured and aggregation-prone proteins.
Applications
Explore how our solutions are used across a range of applications. From sample preparation to advanced analysis, you can find insights into how they support different workflows and help address common challenges.
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Site-specific IgM digestion under physiological conditions, producing homogeneous fragments for precise middle-level LC-MS characterization.
Site-specific digestion of human IgA2m1, generating homogeneous Fab and Fc fragments for high-resolution middle-level LC-MS characterization.
Site-specific digestion of human IgA1, generating homogeneous Fab and Fc fragments for high-resolution middle-level LC-MS characterization.
Removal of N- and O-glycans from complex and heavily glycosylated proteins, enables clear, interpretable LC-MS analysis.
Consistent proteolytic activity delivered with no detectable autoproteolysis, enabling cleaner LC–MS data and more confident peptide identification.
Efficient peptide mapping of antibodies with minimal missed cleavages and high sequence coverage for confident PTM identification.
Superior digestion efficiency with high lysine specificity, generating more unique peptides for confident protein identification in complex proteomics workflows.
Native removal of O-glycans and removal of inaccessible N-glycans under denaturing conditions, enables complete glycan analysis of the complex C1-inhibitor
Robust and reproducible digestion of dulaglutide linkers, separating GLP-1 peptides from the Fc for domain-specific LC-MS analysis of protein modifications
Efficient digestion of multi-domain BiTE molecules, separating the domains for high-quality LC-MS analysis and precise localization of protein modifications
Efficient digestion of hinge-mutated antibodies, generating fragments for comprehensive subunit LC-MS analysis of engineered IgG formats
