Confirmation and quantification of Tn antigens on O-glycosylated biopharmaceuticals while simplifying intact-mass analysis and revealing protein variants.
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Removal of glycan β-galactose to simplify IgG glycan heterogeneity, improve LC-MS analysis, and reveal underlying glycation modifications.
Functional comparison of antibody glycoforms by combining glycoengineering with ADCC and ADCP reporter assays to assess Fc effector activity.
Higher-resolution flow cytometry with improved signal intensity and a 10-fold increase in separation index using site-specific antibody labeling.
Supports high-quality immunofluorescence imaging with consistent signal intensity and reliable quantification through defined antibody labeling.
Improved PET/CT tumor targeting and biodistribution using site-specific antibody labeling with consistent DOL and preserved in vivo performance.
Site-specific ADC generation with defined DAR, preserving antigen binding and delivering potent, controlled cytotoxicity in target cells.
Arginine-specific peptide mapping with improved perfomance over Arg-C, generates larger peptides complementary to trypsin.
Selective removal of α1-2/3/4 fucose for more comprehensive N- and O-glycan characterization.
Rapid and complete defucosylation of O-glycans on TNFR proteins, outperforming alternative fucosidases across glycoengineered substrates.
Generation of defined IgG subunits via single-site, below hinge cdigestion, enabling high-resolution middle-level LC-MS and improved PTM characterization.
Fast and reliable middle-level analysis of antibody oxidation using FabRICATOR and GlycINATOR, supporting robust QC of critical quality attributes.
