Complete Fc N-glycan removal under native conditions, enabling simplfied subunit LC-MS analysis of therapeutic antibodies.
Applications
Explore how our solutions are used across a range of applications. From sample preparation to advanced analysis, you can find insights into how they support different workflows and help address common challenges.
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Generation and purification of F(ab’)2 and scFc fragments without residual enzyme, enabling rapid preparation of antibody fragments for downstream applications.
Comprehensive N-glycan profiling using released glycan workflow, supporting sensitive detection and monitoring of critical quality attributes.
Isotype-specific digestion of IgM and IgG in serum, allowing simultaneous analysis without enzymatic cross-interference.
Subclass selective digestion of IgA in complex samples like serum, enabling targeted analysis of IgA1 and IgA2m1 without off-target cleavage.
Above hinge digestion at a single lysine residue, producing defined fragments for robust LC-MS analysis of LALA-engineered IgG1 antibodies.
Rapid generation of sialylated IgG Fc-glycan profiles, with or without core fucose, for structural and functional characterization.
Rapid and simple generation of IgG with defined Man5 glycoforms for structural and functional characterization.
Rapid generation of galactosylated IgG with or without core fucose for structural and functional characterization.
Simple and rapid generation of IgG with homogeneous G0F or G0 glycoforms for structural and functional characterization.
Hydrolyzes core 1 O-glycans from native glycoproteins, supporting LC-MS workflows for accurate PTM mapping and protein characterization.
IgM-specific digestion with no off-target cleavage of IgG or IgA, enabling selective generation of Fab’ and Fc fragments.
