Hydrolyzes core 1 O-glycans from native glycoproteins, supporting LC-MS workflows for accurate PTM mapping and protein characterization.
Applications
Explore how our solutions are used across a range of applications. From sample preparation to advanced analysis, you can find insights into how they support different workflows and help address common challenges.
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IgM-specific digestion with no off-target cleavage of IgG or IgA, enabling selective generation of Fab’ and Fc fragments.
Highly specific digestion of IgA, with no activity on IgG or IgM, enabling targeted middle-level characterization of IgA1 and IgA2 subclasses.
Highly specific arginine-specific protease with limited off-target digestion, enabling clean peptide maps and high-confidence LC-MS data analysis.
Above-hinge digesiton of human IgG antibodies and Fc-fusion proteins, enabling robust characterization of engineered and hinge-mutated biotherapeutics.
High efficiency and peptide coverage maintained in strong denaturants, supporting analysis of highly structured and aggregation-prone proteins.
Consistent proteolytic activity delivered with no detectable autoproteolysis, enabling cleaner LC–MS data and more confident peptide identification.
