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how the conjugation method affects antibody functions such as binding affinity, stability, and internalization in target positive cell lines. Compared to interchain cysteine conjugation, we obtain more stable ADCs with…


FabRICATOR References

Zaborowska, and Jonathan Bones National Institute for Bioprocessing Research and Training (NIBRT) Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls 2017-11-21 Valegh…


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…diagnostic, other than the following exception which is included within the license: digesting IgG in vitro in clinical samples for diagnostic purposes. This license is defined in the intellectual property…


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Seller in writing within fifteen (15) days of Buyer’s receipt of knowledge of any accident, or incident involving Seller’s products which results in personal injury or damage to property, and…



Binding, and Increased Tumor Uptake In Vivo Antibody Engineering, 2017 OpeRATOR In-depth LC-MS Analysis of O-glycosylated Biopharmaceuticals Using an O-glycan Specific Endoprotease CASSS MS 2019 Analysis of O-glycosylated Biopharmaceuticals using…



B Where does FabRICATOR cleave the IgG molecule? FabRICATOR® cleave the IgG molecule in one specific site in the lower hinge region of the anitbody leaving a F(ab’)2 fragment and…



B Is it possible to digest the glycoprotein with OpeRATOR first and then enrich the O-glycopeptides on GlycOCATCH? No, when the glycoprotein is digested with OpeRATOR, the binding capacity of…


FragIT kit

high specific affinity for the Fc. Both protein A and MabSelect Sure (GE) may have affinity for the Fab which may result in a lower recovery of the generated F(ab’)2…