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ADC Development

  ADC Development Page Specific Links Two-step Cleavable Linkers Payloads-PNU-and-MMAE Site-specific-ADC-Generation Potent and Functional ADCs Site Links All Applications All SmartEnzymes Book a Meeting Resources Site-specific Generation of Custom ADCs…

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Resources

N- and O-glycans on Biopharmaceuticals FoB, 2020 GlycINATOR Therapeutic Antibodies Trimmed with GlycINATOR® Loses Antibody-Dependent Cell-mediated Cytotoxicity Antibody Industrial Symposium, 2018 GingisREX (RgpB) RgpB – an Arginine Specific Protease with…

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Digestion of Human IgM

with and without the loss of the C-terminal tyrosine. The analysis was performed by reversed-phase LC-MS using a Waters™ BioAccord™ LC-MS system. Isotype-specific Digestion using IgMBRAZOR™ IgMBRAZOR is isotype-specific towards…

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SialEXO

Tris pH 7. If denaturing reaction conditions are required for PNGaseF, the reaction with SialEXO needs to be performed first under native conditions, then add PNGaseF and the required buffer….

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Gene Therapy

(2020). https://doi.org/10.1038/s41591-020-0911-7 Elmore ZC, Oh DK, Simon KE, Fanous MM, Asokan A. Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme. JCI Insight. 2020 Sep 17;5(19):e139881. doi: 10.1172/jci.insight.139881…

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IgASAP

IgASAP Sub1 digest human IgA1-only? IgASAP Sub1 may digest IgA1 from other primate species with similar hinge sequences, but this has not been tested. IgASAP Sub1 does not digest IgA2….

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Automated Antibody Subunit Analysis

attributes (CQAs) such as glycosylation, oxidation, and C-terminal lysine clipping. Such detailed knowledge of post-translational modifications (PTM) is required for the development and manufacturing of biopharmaceuticals. FabRICATOR HPLC provides rapid…

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Efficient Hydrolysis of Galactose

Galactosidase Activity on β1-3 Galactose from Etanercept GalactEXO also display enzymatic activity on β1-3 linked galactose present on O-glycosylated biopharmaceuticals such as etanercept. Etanercept was incubated with GalactEXO or galactosidases…

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Sugar-free Proteins in a Few Hours

B Does OmniGLYZOR remove all N-glycans? OmniGLYZOR hydrolyzes the amide bond between the polypeptide asparagine and the innermost GlcNAc of all mammalian asparagine-linked complex, hybrid, or high mannose oligosaccharides. It…

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GlySERIAS

B There are not yet any FAQ’s for this product If you have a technical question, please contact us….

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