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time we handle the antibody sample is when we pipet the sample into the 96 well plate, where the digestion is performed subsequently. In other words, the FabRICATOR MagIC workflow…



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FabRICATOR References

Emmanuelle Leize-Wagner, Yannis-Nicolas François, Middle-level IM-MS and CIU experiments for improved therapeutic immunoglobulin isotype fingerprinting 2020-01-21 Thomas Botzanowski, Oscar Hernandez-Alba, Martine Malissard, Elsa Wagner-Rousset, Evolène Deslignière, Olivier Colas, Jean-François Haeuw,…


Legal & Disclaimers

Fisher Scientific, 5826 Newton Drive, Carlsbad, CA 92008 USA or The trademark POROS® trademark is the property of Life Technologies Corporation. FabRICATOR® MagIC The trademarks Thermo Scientific™, KingFisher™ and…


FabRICATOR MagIC Application

reduction of the disulfide bonds leads to the separation of the F(ab’)2 into the smaller LC and Fd’ subunits, allowing for a more detailed analysis of the resulting subunits. This


ADC Development

…, the linker- glycoside is hydrolyzed by the lysosomal β-glucuronidase. Removal of the glycoside exposes the peptide linker to proteolytic cleavage by the lysosomal protease cathepsin B, releasing the toxi…


Data Protection Policy

interests are processing for business purposes, marketing, IT security, communication and development. Contact Details If you have any questions, comments or complaints regarding this policy, please contact us at


Antibody Fc-glycan Analysis

fragment, enabled a fast analysis of the glycan profile. The measured monoisotopic masses of Fc/2, LC and Fd’ fragments were compared to theoretical data and the relative distribution of the


VP Sales & Marketing

For more information about Genovis, please visit our website The Position The VP Sales & Marketing reports directly to CEO and is part of the Senior Management team at…


Automated Antibody Subunit Analysis

any risk of over-digestion, Figure. 1.   Figure 1. FabRICATOR digests IgGs to F(ab´)2 and Fc. After reduction, the size of the fragments Fd’, Fc/2 and LC are 23–25 kDa,…