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SmartStories

longer acting medicines, we have developed IgG and Fc-fusion mimetics called Fab-PEG-Fab (FpF) and receptor-PEG-receptor (RpR). Antibody fragments (Fabs) and receptor-binding fragment (VEGFR1-VEGFR2) are obtained by proteolytical digestion of IgG…

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Scientific, 5826 Newton Drive, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. The trademark POROS® trademark is the property of Life Technologies Corporation. FabRICATOR® MagIC The trademarks Thermo Scientific™, KingFisher™ and BindIt™…

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Hydrolysis of Flexible Linkers

approaches for detailed characterization of fusion proteins, multi-specific antibodies and various mAb fragments containing glycine-rich linkers. GlySERIAS Reproducible Digestion of a GS-linked Fusion Protein The fusion protein dulaglutide consists of…

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Digestion of IgA

of the substrates. To demonstrate the site-specificity of IgASAP Sub1+2, a commercially available recombinant human IgA2m1 was digested with IgASAP Sub1+2 Lyophilized overnight at 37°C, and compared to the undigested…

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Data Protection Policy

guarantee that personal data are protected from unauthorized access or disclosure, changes, or destruction, despite our physical, technological and administrative security measures. Legal Grounds for Processing Personal Data Genovis processes…

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Terms and Conditions

Free Carrier, INCOTERMS 2020, Kävlinge SWEDEN. The price includes Genovis to clear the product/processed Material for export if applicable. However, Genovis has no obligations to clear the product/processed Material for

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Fluorescent imaging

Indirect detection methods require several incubation steps and secondary antibodies are a potential source of unsolicited background staining due to unspecific binding or cross-reactivity.Site-specific and quantitative conjugation using GlyCLICK enables…

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SmartEnzymes for Gene Therapy

(2020). https://doi.org/10.1038/s41591-020-0911-7 Elmore ZC, Oh DK, Simon KE, Fanous MM, Asokan A. Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme. JCI Insight. 2020 Sep 17;5(19):e139881. doi: 10.1172/jci.insight.139881…

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FabRICATOR MagIC Application

platforms High throughput parallel analysis of antibodies Complete digestion in 10-20 minutes Fast parallel sample preparation with minimal hands-on time Therapeutic antibodies and other IgG-based biopharmaceuticals require careful characterization and…

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