GingisKHAN® (KGP)

GingisKHAN enzyme is a unique protease that digests human IgG1 between K223 and T224 producing a homogenous pool of Fab and Fc fragments. The enzyme requires only mild reduced condition for activity and the reaction is performed in the presence of 2 mM Cystein at neutral pH, leaving intact Fab and Fc fragments.

Key Characteristics

  • Specific - one precise cleavage site in upper hinge of human IgG1
  • Rapid – 60 minute protocol for complete digestion
  • Comes with ready to use reaction buffer additive for convenient and reliable performance

GingisKHAN® Digestion Site


Visit Applications to view the IgG protease digestion chart

Product Formats

GingisKHAN® Enzyme

GingisKHAN enzyme supplied as lyophilized powder together with 5 vials of lyophilized GingisKHAN reducing agent for convenient and reliable performance. The enzyme is available in 2000 unit vial (1 unit digest 1 ug IgG).

GingisKHAN® Fab kit

GingisKHAN Fab kit is used for rapid and easy preparation and purification of of Fab fragments from human IgG1 antibodies. The kit consists of two parts; lyophilized GingisKHAN enzyme and affinity spin columns for purification of intact Fab fragments.

Documents and References

Enzyme Reference Tool

All published papers on how Genovis enzymes help simplify antibody analytics

FAQ and Support


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Patent and Disclaimer


The trademark GingisKHAN is the property of Genovis AB.

For research use only. Not intended for any animal or human therapeutic diagnostic use.
©2016 Genovis AB.