



IgG Proteases
The Genovis product line of IgG proteases consists of:
FabRICATOR - a cysteine protease digesting IgG at a specific site below the hinge
FabALACTICA - a cysteine protease digesting human IgG1 at a specific site above the hinge
GingisKHAN - a cysteine protease digesting human IgG1 at a specific site above the hinge
FabULOUS - a cysteine protease digesting IgG in the hinge region
FabRICATOR Z - a cysteine protease digesting mouse IgG2a at a specific site below the hinge
An overview of the enzymes is presented on this page. Please visit the individual product pages for full details on the different IgG proteases.
Overview
Our proteases digest IgG at different sites. An overview of the digestion sites in human IgG1 is found in the picture to the right.


- Human IgG1-4, IgG from monkey, rat, rabbit and sheep
- 30 min reaction
- No need for reducing agents or co-factors
- CPAPELLG / GPSVF (below the hinge)
- Human IgG1
- Overnight (O/N) reaction
- No need for reducing agents or co-factors
- KSCDKT / HTCPPCP (above the hinge)
- Human IgG1
- 60 min reaction
- 2 mM cysteine (included)
- KSCDK / THTCPPCP (above the hinge)
- Human IgG1-4, IgG from mouse, rat, goat, sheep and rabbit
- 60 min reaction
- Requires reducing conditions
- Human IgG1: KTHT / CPPCPAP (above the hinge)
- Mouse IgG2a and IgG3, IgG from monkey, rabbit and sheep
- 2 h reaction
- No need for reducing agents or co-factors
- CPAPNLLG / GPSVF (below the hinge)
Legal and Disclaimers
All rights reserved. Genovis products are covered by one or more patents, pending patent applications, trademarks and/or copyrights owned or controlled by Genovis AB.
For more information about commercial rights, please contact Genovis team at info@genovis.com.
Genovis products are intended for research use only. They are not intended to be used for therapeutic or diagnostic purposes in humans or animals.