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SialEXO workflow

SialEXO®

The SialEXO family are sialidase products for the removal and analysis of sialic acids. The enzymes are active on N- or O-linked glycans present on native glycoproteins or released glycan structures.

 

SialEXO is available in three different product formats:

  • SialEXO - sialidase mix for complete removal of sialic acids (α2-3, α2-6 & α2-8)
  • SialEXO 23 - an α2-3 specific sialidase
  • Immobilized SialEXO - immobilized SialEXO on agarose beads

Product Information

The SialEXO family are sialidase products for the removal and analysis of sialic acids on native glycoproteins or on released glycans. The sialidases have unique activities and they work fast with no need for co-factors. They are active on both N- and O-linked glycans.

Product Formats

SialEXO®

SialEXO for complete removal of sialic acids (α2-3, α2-6 and α2-8). It is supplied as a lyophilized powder. SialEXO is available in 2000 unit vials for desialylation of up to 2 mg glycoprotein.

SialEXO® 23

SialEXO 23 for complete removal of α2-3 sialic acids. It is supplied as a lyophilized powder. The enzyme is available in 500 unit vials for desialylation of up to 0.5 mg glycoprotein.

Immobilized SialEXO®

SialEXO immobilized on agarose beads, allowing for desialylation of 0.5 mg glycoprotein in 30 minutes without enzyme in the final preparation.

Key Characteristics

  • Hydrolyzes sialic acids on N- and O-linked glycans
  • α2-3, α2-6 and α2-8-linked sialic acids
  • 30 min - 2 h reaction
  • Requires no co-factors

Applications

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Brochures and Posters

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Applications

Applications

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SmartStories

Analytical services lab exploit SialEXO, FragIT and OglyZOR.

External References and Reference Tool

SialEXO references

References

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Smart Enzyme Reference Tool

SmartEnzyme Reference Tool

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FAQ

Yes, SialEXO can be incubated together with OpeRATOR and/or OglyZOR in 20 mM Tris pH 6.8.
Yes, both enzymes are active under neutral conditions, preferably use 20 mM Tris pH 7.
Yes, SialEXO contains a 6x His-tag.

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Legal and Disclaimers

All rights reserved. Genovis products are covered by one or more patents, pending patent applications, trademarks and/or copyrights owned or controlled by Genovis AB.

For more information about commercial rights, please contact Genovis team at info@genovis.com.

Genovis products are intended for research use only. They are not intended to be used for therapeutic or diagnostic purposes in humans or animals.

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