Enzymes for O-glycans

Enzymes for O-glycan Analysis

The Genovis product line of enzymes for O-glycans consists of:

OpeRATOR® – O-protease for O-glycan-specific digestion of mucin-type glycoproteins

GlycOCATCH® – Tool for enrichment of mucin-type O-glycosylated proteins and peptides

OglyZOR® – Endoglycosidase (O-glycosidase) for O-glycans of core 1 and core 3

SialEXO® – Exoglycosidase acting on sialic acids

An overview of the enzymes are presented on this page. Please visit the individual product pages for full details on the different enzymes for O-glycans.


 Enzymes for O-Glycans operator logo

OpeRATOR is an O-glycan-specific protease that digests mucin-type O-glycosylated proteins N-terminally of Ser and Thr glycosylation sites.

Key Characteristics

  • Digests native mucin-type O-glycosylated proteins
  • 2h to overnight (16-18h) reaction
  • Desialylation using SialEXO® (included) increases performance
  • N-terminally of mucin-type O-glycosylated serine and threonine residues

Enzymes for O-Glycans glycocatch

GlycOCATCH is an enrichment resin for affinity purification of mucin-type O-glycosylated proteins and peptides.

Key Characteristics

  • Binds mucin-type O-glycosylated proteins and peptides
  • 2h binding
  • Desialylation using SialEXO® (included) increases binding
  • Glycoproteins and peptides carrying mucin-type O-glycans

Enzymes for O-Glycans oglyzor

OglyZOR is an O-glycosidase that specifically hydrolyzes core 1 and core 3 type O-glycans on native glycoproteins.

Key Characteristics

  • Hydrolyzes O-glycans on glycoproteins
  • 2-4h reaction
  • Requires removal of sialic acids using SialEXO® (included)
  • Core 1 and core 3 type O-glycan disaccharides

Enzymes for O-Glycans sialexo

SialEXO is a sialidase mix for complete removal of sialic acids from 2 mg native glycoprotein.

Key Characteristics

  • Hydrolyzes sialic acids on N- and O-linked glycans
  • 2 h reaction
  • Requires no co-factors
  • α2-3, α2-6 and α2-8-linked sialic acids





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