Immobilized FabALACTICA

380.003,470.00

Immobilized FabALACTICA generates intact Fab and Fc fragments from human IgG1

380.00
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Description

Immobilized FabALACTICA contains FabALACTICA (IgdE) enzyme immobilized on agarose beads. The immobilized enzyme digests human IgG1 at one single amino acid position above the hinge generating intact Fc and Fab fragments. Immobilized FabALACTICA is available in spin columns for digestion of 0.5 – 100 mg of human IgG1 without residual enzyme in the final preparation.

Detailed Information

Application

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Product Composition

Digestion Site

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Unit Definition

FAQs

Yes, for human IgG1 molecules both enzymes can be used in combination to generate a specific hinge peptide. The incubation time is significantly longer for FabALACTICA and it is recommended to first run the FabALACTICA digest and then add FabRICATOR for the last 30 min.

FabALACTICA does not require reducing conditions as both GingisKHAN and FabULOUS does, and allows for generation of Fab fragments from native human IgG1.

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