FabULOUS

470.00

FabULOUS (SpeB) digests IgG from several species in the hinge under reducing conditions

470.00
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Description

FabULOUS (SpeB) is a cysteine protease that digests IgG from several different species and subclasses in the hinge region generating Fc and Fab fragments. FabULOUS digests human IgG1 at a specific site above the hinge while IgG from other species and subclasses such as mouse IgG1 is digested in the hinge region. FabULOUS requires reducing conditions and is available as lyophilized powder for digestion of 2 mg of IgG.

Detailed Information

Application

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Product Group

Source/Origin

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Product Composition

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Digestion Site

Specificity

Substrates

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Reaction Conditions

Digestion Buffers

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Buffer Compatibility

Additives/Co-factors

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Inhibitors

Unit Definition

FAQs

Yes, FabULOUS requires reduced condition for activity and reaction is performed in the presence of 1-5 mM DTT or TCEP at neutral pH.

FabULOUS enzyme reaction is inhibited with iodoacetamide, iodo acetic acid or lowering pH below 3.

Yes, but a longer incubation time is needed.

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