FabALACTICA

560.00

FabALACTICA digests human IgG1 at a single site above the hinge

560.00
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Description

FabALACTICA (IgdE) is a cysteine protease that digests human IgG1 at one single amino acid position above the hinge generating intact Fc and Fab fragments. FabALACTICA is available as lyophilized powder for digestion of 2 mg of human IgG1 without the need of reducing conditions.

Detailed Information

Application

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Product Group

Source/Origin

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Product Composition

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Digestion Site

Specificity

Substrates

Reaction Conditions

Digestion Buffers

Buffer Compatibility

FAQs

Yes, for human IgG1 molecules both enzymes can be used in combination to generate a specific hinge peptide. The incubation time is significantly longer for FabALACTICA and it is recommended to first run the FabALACTICA digest and then add FabRICATOR for the last 30 min.

FabALACTICA does not require reducing conditions as both GingisKHAN and FabULOUS does, and allows for generation of Fab fragments from native human IgG1.

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