Digested Guide to ASMS 2024

May 30, 2024 | Conferences |

At the annual ASMS meeting, we proudly showcase the latest SmartEnzymes™ applications! Many of our customers will also present posters and oral presentations, highlighting how SmartEnzymes have enhanced their specific projects. This digested guide to ASMS features the most anticipated posters and presentations that we’re excited about. We hope it inspires you and helps you plan your schedule at ASMS!


Monday June 3

Poster highlight:
MP 280 An Innovative Method for Analyzing IgG Glycosylation Significance in Traumatic Brain Injury
📢 Oral presentation: Automated Real Time High-Speed Microdroplet Reactions to Increase the Throughput of Therapeutic Protein Characterization
Krishna Anapindi / Ballroom AB (Level 3) / 3:50pm – 4:10pm (Pacific)
Gilead Sciences Foster City CA


Tuesday June 4

🌟 TP 505: Fractionation of Bispecific Antibody Charge Variants by MauriceFlex™ and their Identification by Mass Spectrometry
Srinivasa Rao; Andreas Nageli; Chris Heger.
Bio-Techne, San Jose, CA, Genovis AB, Kävlinge, Sweden
🌟 TP 649: A middle-level approach to simplify sample preparation and data analysis for characterization of the fusion protein blinatumomab
Lucy Fernandes; Andreas Nägeli; Magdalena Widgren-Sandberg; Antony Harvey.
ProteinMetrics LLC, Cupertino, CA; Genovis, Kävlinge, Sweden
📢 Oral presentation: Digging into the multifaceted variability of antibody molecules: Fc-proteoform profiling illuminates autoimmune responses in rheumatoid arthritis
Elena Domínguez-Vega / Ballroom DE (Level 3) / 9:50am – 10:10am (Pacific)
Center for Proteomics and Metabolomics, Leiden University Medical Center Leiden South Holland
More poster highlights:
TP 623 O-glycosylation characterization of rhTPO based on EAD mass spectrometry
TP 631 Analytical Challenges in the Characterization of a Complex Fc Fusion Protein
TP 646 Flash Characterization of mAbs using a Combination of Reagents via Automated On-Line Microdroplet Reaction
TP 749 Exploring Digestion Enzymes for Online Microdroplet-Enabled Analysis of LC Separated mAbs


Wednesday June 5

🌟 WP 036: Rapid Quality Assessment of Therapeutic Monoclonal Antibodies through Automated Middle-level Mass Spectrometry
Andreas Naegeli; Olle De Bruin; Phil Widdowson; Camilla Sivertsson; Gunilla Larsson; Rolf Lood.
Genovis AB, Kävlinge, Sweden; BioInvent International AB
🌟 WP 499: Paving the Fast Lane of Biotherapeutic Discovery: Enhancing Throughput via Pre-Allocated Enzyme-Loaded PNGase F Plates for N-Linked Glycan Removal
Olivia Huffman
Eli Lilly & Co, San Diego
📢 Oral presentation: Interpreting the Structural Polymorphism of Fc-Fusion Proteins using Ion Mobility-Collision Induced Unfolding (IM-CIU)
Addison Bergman / Room 304AB (Level 3) / 3:10pm – 3:30pm (Pacific)
University of Michigan Department of Chemistry Ann Arbor MI
More poster highlights:
WP 012 Characterization of a site-specific antibody-drug conjugate using native mass spectrometry and electron activated dissociation-based middle-down workflows
WP 025 Rapid LC-MS methods to de-risk complex novel biologics using middle-level characterisation: enhancing our early stage research developability assessments
WP 031 Localization and Quantification of Lysine Conjugation by Peptide Mapping
WP 629 Development of a novel middle-up HILIC-MS method for intra-domain free thiol localization and quantitation in therapeutic monoclonal antibodies


Thursday June 6

Poster highlights:
ThP 026 Enhancing drug-payload localization in antibody-drug conjugates with a middle-down approach utilizing proton transfer charge reduction on a modified Orbitrap Ascend
ThP 029 Studying Fab glycosylated antibody pharmacokinetics in human plasma samples at the subunit level by nano-RP-LC-MS
ThP 030 Considerations for Accurate Determination of Drug-to-Antibody Ratio (DAR) of Highly-loaded Antibody Drug Conjugates (ADCs) with DAR of 8 by LC-MS
ThP 031 LC-MS/MS and EndoS2 Workflow for Knock Out Verification of FUT8, the Gene Encoding for α-(1,6) Fucosyltransferase in CHO Cells
ThP 561 A modified SLIM-IM-QTOF for high resolution collision induced unfolding and native protein analysis