Fully automated 3D LC-MS workflow for the characterization of antibody glycosylation

Genentech used FabRICATOR®-HPLC to develop a fast and automated 3D LC-MS workflow for the characterization of glycosylation on therapeutic antibodies.   The glycosylation profile is a critical quality attribute of biopharmaceuticals including antibodies. This heterogenous quality attribute can be tackled using a range of different analytical technologies including separation of released glycans , intact glycoprotein … Continue reading Fully automated 3D LC-MS workflow for the characterization of antibody glycosylation