Antibody Fragmentation
The fastest and most accurate enzymatic tool for generating F(ab’)2 and Fab fragments from antibodies.
FabRICATOR is a novel proteolytic enzyme with unique proteolytic specificity. FabRICATOR cleaves all human, rabbit, sheep and monkey IgG subclasses at the same position just below the hinge region. This generates F(ab’)2 fragments without further degradation or over-digestion commonly associated with other proteolytic enzymes like pepsin or papain. Learn more about the FabRICATOR enzyme.
The FabRICATOR enzyme has been further developed and immobilized on agarose for even more convenient use and handling. FragIT spin columns consists of FabRICATOR immobilized on agarose and allows for rapid and clean fragmentation of antibodies. FragIT-Kit simplifies the whole process of fragmentation and purification of F(ab')2 or Fab' fragments.
